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Showing 1–5 of 5 results
Advanced filters: Author: Blake Lash Clear advanced filters

  • R2 retrotransposons are natural RNA guided gene insertion systems. Here, Edmonds et al. characterize the structure and biochemistry of an avian R2 and engineer a compact, all-RNA system to integrate DNA in mammalian cells, aiding the development of future retrotransposon-based gene editors.

    • KeHuan K. Edmonds
    • Max E. Wilkinson
    • Feng Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • CRISPR-mediated genome editing tools are entering the clinic, but concerns remain about the potential immunogenicity of these bacterial-derived proteins. Here, Raghavan et al. engineer two Cas effectors, Cas9 and Cas12, for reduced immunogenicity in vivo while maintaining on-target activity.

    • Rumya Raghavan
    • Mirco J. Friedrich
    • Feng Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Tan, Lash et al. show that blocking the Interleukin-1 receptor promotes rapid wound closure in diabetic mice. They engineered a matrix binding form of Interleukin-1 receptor antagonist (IL-1Ra) that has the ability of precise localisation and retention in the tissue. IL-1Ra holds the potential for expediting wound healing in diabetic patients.

    • Jean L. Tan
    • Blake Lash
    • Mikaël M. Martino
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11

  • The tail fibre of an extracellular contractile injection system (eCIS) from Photorhabdus asymbiotica recognizes targets expressed on eukaryotic host cells, and can be reprogrammed to target specific organisms and cell types for delivery of novel protein payloads.

    • Joseph Kreitz
    • Mirco J. Friedrich
    • Feng Zhang
    ResearchOpen Access
    Nature
    Volume: 616, P: 357-364