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Showing 1–3 of 3 results
Advanced filters: Author: Bob Fregin Clear advanced filters

  • High-throughput rheological measurements of cells and cell clusters by microfluidics is limited by fixed channel dimensions. Here the authors create virtual fluidic channels inside the cuvette of commercial flow cytometers to dynamically tune channel cross section to enable rheological measurements from cells and cell clusters.

    • Muzaffar H. Panhwar
    • Fabian Czerwinski
    • Oliver Otto
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Real-time deformability cytometry (RT-DC) is used for mechanical cell phenotyping but is limited to a single snapshot per cell and can only measure elastic modulus. Here the authors introduce dynamic RT-DC which can measure elasticity and viscosity in single cells by following dynamic cell shape changes.

    • Bob Fregin
    • Fabian Czerwinski
    • Oliver Otto
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Reactive oxygen species (ROS), such as hydrogen peroxide, play a key role in cellular processes but can cause damage at high concentrations. The authors demonstrate that elevated ROS levels are accompanied by an increased cell stiffness that is explained by cytosolic acidification due to lysosomal degradation and not by alterations in the cytoskeleton.

    • Yesaswini Komaragiri
    • Ricardo Hugo Pires
    • Oliver Otto
    ResearchOpen Access
    Communications Physics
    Volume: 7, P: 1-12