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Showing 1–2 of 2 results
Advanced filters: Author: Boguslawa Sadowski Clear advanced filters

  • Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelin repair in adult mice, but is defective with aging.

    • Sarah Moyon
    • Rebecca Frawley
    • Patrizia Casaccia
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Myelin is formed of proteins of long half-lives. The mechanisms of renewal of such a stable structure are unclear. Here, the authors show that myelin integrity requires continuous myelin synthesis at the inner tongue, contributing to the maintenance of a functional axon-myelin unit.

    • Martin Meschkat
    • Anna M. Steyer
    • Wiebke Möbius
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18