Nature Search

Author Correction: Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

Bojana Lucic
Heng-Chang Chen
Marina Lusic
Amendments and CorrectionsOpen Access28 Oct 2021
Nature Communications

Volume: 12, P: 1
Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

HIV-1 usually targets active genes and integrates near the nuclear pore compartment. Here the authors show that recurrently targeted genes are proximal to super-enhancer genomic elements, which cluster in specific spatial compartments of the T cell nucleus, suggesting a role for nuclear organisation in viral infection.

Bojana Lucic
Heng-Chang Chen
Marina Lusic
ResearchOpen Access06 Sept 2019
Nature Communications

Volume: 10, P: 1-12
Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions

R-loops formed by RNA hybridization to DNA template strand during transcription influence HIV-1 integration into the CD4⁺ T cell genome. The unwinding of R-loops by splicing helicase Aquarius facilitates integration into speckle-associated domains.

Carlotta Penzo
Ilayda Özel
Marina Lusic
Research20 Aug 2025
Nature Microbiology

Volume: 10, P: 2306-2322
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction

CLPP-deficiency-driven mitochondrial dysfunction in brown adipose tissue leads to the accumulation of d-2-hydroxyglutarate, in turn promoting lipid-droplet enlargement by altering gene expression and epigenetically regulating nuclear stiffness.

Harshita Kaul
Lea Isermann
Aleksandra Trifunovic
ResearchOpen Access01 Aug 2025
Nature Metabolism

Volume: 7, P: 1593-1613
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

The cytotoxic effects of topoisomerase I inhibitors such as camptothecin can be modulated by replication fork reversal, in a process that requires Poly(ADP-ribose) polymerase (PARP) activity. Here human RECQ1 helicase is shown to restore such regressed replication forks, whereas PARP1 activity restrains this RECQ1 function.

Matteo Berti
Arnab Ray Chaudhuri
Alessandro Vindigni
Research10 Feb 2013
Nature Structural & Molecular Biology

Volume: 20, P: 347-354
Nuclear architecture dictates HIV-1 integration site selection

HIV-1 integration into the host cell genome occurs in the outer shell of the nucleus in close correspondence with the nuclear pore, in which a series of cellular genes are preferentially targeted by the virus.

Bruna Marini
Attila Kertesz-Farkas
Marina Lusic
Research02 Mar 2015
Nature

Volume: 521, P: 227-231

Search

Filter By:

Author Correction: Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions

2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

Nuclear architecture dictates HIV-1 integration site selection

Search

Quick links