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The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism

Cancer cells adapt to changes in metabolism to ensure their survival. Here the authors show that glucose responsive transcription factor ChREBP reprograms liver cancer metabolism in part via enhancing the PI3K/AKT signaling.

Emmanuel Benichou
Bolaji Seffou
Renaud Dentin
ResearchOpen Access29 Feb 2024
Nature Communications

Volume: 15, P: 1-29
Reduced central and peripheral inflammatory responses and increased mitochondrial activity contribute to diet-induced obesity resistance in WSB/EiJ mice

Jérémy Terrien
Isabelle Seugnet
Marie-Stéphanie Clerget-Froidevaux
ResearchOpen Access23 Dec 2019
Scientific Reports

Volume: 9, P: 1-19

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The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism

Reduced central and peripheral inflammatory responses and increased mitochondrial activity contribute to diet-induced obesity resistance in WSB/EiJ mice

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