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Showing 1–7 of 7 results
Advanced filters: Author: Boleslaw Lach Clear advanced filters

  • Analysis of medulloblastomas in humans and mice shows that the functional consequences of ZIC1 mutations are exquisitely dependent on the cells of origin that give rise to different subgroups of medulloblastoma.

    • John J. Y. Lee
    • Ran Tao
    • Michael D. Taylor
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 88-102

  • Medulloblastoma is the most common malignant brain tumour in children; having assembled over 1,000 samples the authors report that somatic copy number aberrations are common in medulloblastoma, in particular a tandem duplication of SNCAIP, a gene associated with Parkinson’s disease, which is restricted to subgroup 4α, and translocations of PVT1, which are restricted to Group 3.

    • Paul A. Northcott
    • David J. H. Shih
    • Michael D. Taylor
    ResearchOpen Access
    Nature
    Volume: 488, P: 49-56

  • Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular convergence of MYCN and cAMP signaling pathways.

    • Patryk Skowron
    • Hamza Farooq
    • Michael D. Taylor
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17