The protein tyrosine phosphatase EYA is shown to be recruited to DNA double-strand breaks after genotoxic stress and to remove a tyrosine phosphorylation modification on histone H2AX. The tyrosine phosphorylation state of H2AX helps to determine whether DNA repair or pro-apoptotic factors are recruited to chromatin, with tyrosine dephosphorylation by EYA promoting repair rather than apoptosis.
- Peter J. Cook
- Bong Gun Ju
- Michael G. Rosenfeld
