Nature Search

Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Sooji Lee
Yejun Son
Nicholas. J. Kassebaum
Research22 Apr 2025
Nature Medicine

Volume: 31, P: 1809-1829
A spatially resolved single-cell genomic atlas of the adult human breast

The Human Breast Cell Atlas identifies 12 major breast cell types and 58 biological cell states, revealing abundant pericyte, endothelial and immune cell populations, and highly diverse luminal epithelial cell states.

Tapsi Kumar
Kevin Nee
Nicholas Navin
Research28 Jun 2023
Nature

Volume: 620, P: 181-191
Normal breast tissues harbour rare populations of aneuploid epithelial cells

Using single-cell DNA sequencing we show that most healthy women harbour rare populations of aneuploid epithelial cells with copy number alteration events in their breast tissue that expand and accumulate with age.

Yiyun Lin
Junke Wang
Nicholas Navin
Research20 Nov 2024
Nature

Volume: 636, P: 663-670
Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key

Bora Lim
Wendy A. Woodward
Naoto T. Ueno
Amendments and Corrections10 May 2018
Nature Reviews Cancer

Volume: 18, P: 526
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions

Hao, Shen and colleagues identify and characterize two distinct types of myeloid–B cell interaction that may signal solid tumour-induced immunosuppression and can correlate with complete responses to immunotherapy in patients with breast cancer.

Xiaoxin Hao
Yichao Shen
Xiang H.-F. Zhang
Research12 Sept 2024
Nature Cell Biology

Volume: 26, P: 1971-1983
Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression

Total mRNA expression in cancer cells is a marker for disease progression and death.

Shaolong Cao
Jennifer R. Wang
Wenyi Wang
ResearchOpen Access13 Jun 2022
Nature Biotechnology

Volume: 40, P: 1624-1633
Breast tumours maintain a reservoir of subclonal diversity during expansion

Single-cell analysis of genomes from primary human breast tumours and cell lines shows that chromosomal aberrations continue to evolve during primary tumour expansion, resulting in a milieu of subclones within the tumour.

Darlan C. Minussi
Michael D. Nicholson
Nicholas E. Navin
Research24 Mar 2021
Nature

Volume: 592, P: 302-308
Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy

Arthritis is the most common rheumatic immune-related adverse event (irAE) occurring in cancer patients receiving immune checkpoint inhibitors. Here the authors study the immune landscape of blood and synovial fluid samples from patients with arthritis-irAE, reporting immunological differences and similarities with classic autoimmune arthritis.

Sang T. Kim
Yanshuo Chu
Roza Nurieva
ResearchOpen Access12 Apr 2022
Nature Communications

Volume: 13, P: 1-19
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis

Phagocytes can acquire lipids and this modulates their function in a variety of disease states, such as atherosclerosis. Ren and colleagues demonstrate that neutrophils accumulate lipids and deliver them to tumor cells, which supports their proliferation, survival and metastasis.

Peishan Li
Ming Lu
Guangwen Ren
Research21 Sept 2020
Nature Immunology

Volume: 21, P: 1444-1455
A phase II study of talimogene laherparepvec for patients with inoperable locoregional recurrence of breast cancer

Megumi Kai
Angela N. Marx
Naoto T. Ueno
ResearchOpen Access15 Nov 2021
Scientific Reports

Volume: 11, P: 1-8
Author Correction: Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy

Sang T. Kim
Yanshuo Chu
Roza Nurieva
Amendments and CorrectionsOpen Access04 Jul 2024
Nature Communications

Volume: 15, P: 1
Gene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons

Dong Won Kim and colleagues investigate the mechanisms by which hypothalamic GABAergic neurons differentiate during development. They report that Lhx6 is crucial for the survival of hypothalamic neurons.

Dong Won Kim
Kai Liu
Seth Blackshaw
ResearchOpen Access21 Jan 2021
Communications Biology

Volume: 4, P: 1-16
Inflammatory breast cancer biology: the tumour microenvironment is key

Although the aggressive underlying biology of inflammatory breast cancer (IBC) remains largely undefined, the tumour microenvironment (TME) has emerged as a key contributor. This Review discusses intrinsic characteristics of IBC, extrinsic features of the TME and intrinsic–extrinsic communication.

Bora Lim
Wendy A. Woodward
Naoto T. Ueno
Reviews27 Apr 2018
Nature Reviews Cancer

Volume: 18, P: 485-499
Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatment

Mokryun L. Baek
Junegoo Lee
Gloria V. Echeverria
Research22 Feb 2023
Oncogene

Volume: 42, P: 1117-1131
Contextualising the developability risk of antibodies with lambda light chains using enhanced therapeutic antibody profiling

A computational analysis of human kappa and lambda antibodies suggests that lambda antibodies are frequently less therapeutically developable due to their physicochemical properties, but that rational design strategies could reduce this risk.

Matthew I. J. Raybould
Oliver M. Turnbull
Charlotte M. Deane
ResearchOpen Access08 Jan 2024
Communications Biology

Volume: 7, P: 1-13
RANKL immunisation inhibits prostate cancer metastasis by modulating EMT through a RANKL-dependent pathway

Mineon Park
Yong Jin Cho
Wonbong Lim
ResearchOpen Access09 Jun 2021
Scientific Reports

Volume: 11, P: 1-16
A phase Ib study of entinostat plus lapatinib with or without trastuzumab in patients with HER2-positive metastatic breast cancer that progressed during trastuzumab treatment

Bora Lim
Rashmi K. Murthy
Naoto T. Ueno
ResearchOpen Access17 May 2019
British Journal of Cancer

Volume: 120, P: 1105-1112
Improving the odds together: a framework for breast cancer research scientists to include patient advocates in their research

Hillary Stires
Igor Bado
Josh Newby
ReviewsOpen Access30 Jun 2022
npj Breast Cancer

Volume: 8, P: 1-5

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