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Showing 1–12 of 12 results
Advanced filters: Author: Boris N. Kholodenko Clear advanced filters

  • Spatial and temporal dynamics of signalling networks control the specificity of cellular responses to receptor stimulation. Computational models now provide insights into the mechanisms that are responsible for signal amplification, as well as the timing, amplitude, duration and spatial distribution of signalling responses.

    • Boris N. Kholodenko
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 7, P: 165-176

  • The Raf-1 kinase is important for mitogenic MAPK signalling but also inhibits pro-apoptotic Hippo signalling. Kolch and colleagues have found that the Hippo kinase LATS1 phosphorylates Raf-1 in a feedback regulatory loop to inhibit both pathways, and demonstrate by experiments and modelling that competing protein interaction can form the basis for a switch-like transition between signalling pathways.

    • David Romano
    • Lan K. Nguyen
    • Walter Kolch
    Research
    Nature Cell Biology
    Volume: 16, P: 673-684

  • An approach called cell state transition assessment and regulation uses diverse multiomics data to map cell states, model their transitions, and understand the signalling networks that control them.

    • Oleksii S. Rukhlenko
    • Melinda Halasz
    • Boris N. Kholodenko
    Research
    Nature
    Volume: 609, P: 975-985

  • Mitogen-activated protein kinase (MAPK) cascades process myriads of stimuli, generating receptor-specific cellular outcomes. New work exploits emergent mathematics of network inference to reveal distinct feedback designs of the RAF–MEK–ERK cascade induced by two different growth factors. The study shows that response specificity can arise from differential signal-induced wiring of overlapping protein networks.

    • Boris N. Kholodenko
    News & Views
    Nature Cell Biology
    Volume: 9, P: 247-249

  • The discovery of molecular signalling machines such as Ras nanoclusters, spatial activity gradients and flexible network circuitries involving transcriptional feedback, are beginning to reveal the design principles of spatiotemporal organization that are crucial for signalling network function and cell fate decisions.

    • Boris N. Kholodenko
    • John F. Hancock
    • Walter Kolch
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 414-426

  • Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re‐wiring of signalling in response to KRas mutation

    • Susan A. Kennedy
    • Mohamed-Ali Jarboui
    • Walter Kolch
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Cancer cells exhibit huge phenotypic plasticity, which can lead to adaptations to the tumour microenvironment and therapy. Much of this plasticity seems to be encoded in signal transduction networks, such that alterations in signalling dynamics can affect many cancer-associated phenotypes and therapeutic response.

    • Walter Kolch
    • Melinda Halasz
    • Boris N. Kholodenko
    Reviews
    Nature Reviews Cancer
    Volume: 15, P: 515-527