This study reveals a common mechanism for active reboot of consciousness from anesthesia. Ubiquitination degradation of KCC2 in the ventral posteromedial nucleus (VPM) leads to GABAA receptor-mediated disinhibition, triggering and accelerating recovery of VPM neuron activity and consciousness.
- Jiang-Jian Hu
- Yuexin Liu
- Xue-Jun Song
