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Showing 1–6 of 6 results
Advanced filters: Author: Brandi Livingston Clear advanced filters

  • Transmission of influenza A viruses (IAV) between hosts and replication within host impose genetic bottlenecks, constraining viral diversity and adaptation. Here, Amato et al. perform site-specific inoculation of barcoded IAV of ferrets and track viral diversity as infection spreads to the lower respiratory tract and conclude that narrow population bottlenecks are an important feature of the within-host infection dynamics.

    • Katherine A. Amato
    • Luis A. Haddock III
    • Andrew Mehle
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • A newly developed RIPK3 inhibitor blocks necroptosis of lung cells, reduces lung inflammation and prevents mortality in a mouse model of influenza A virus infection.

    • Avishekh Gautam
    • David F. Boyd
    • Siddharth Balachandran
    Research
    Nature
    Volume: 628, P: 835-843

  • Astroviruses are the leading cause of pediatric diarrhea, but which cells are the main targets in the gut remains unclear. Here, using an in vivo model of murine astrovirus, the authors show that the virus infects goblet cells and that this alters mucus production and increases mucus-associated bacterial communities in the gut.

    • Valerie Cortez
    • David F. Boyd
    • Stacey Schultz-Cherry
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Ferrets are the main animal model used for research on influenza transmission. Here, the authors investigate the dynamics of infection and transmission in ferrets using a replication-competent influenza reporter virus and real-time bioluminescence imaging.

    • Erik A. Karlsson
    • Victoria A. Meliopoulos
    • Stacey Schultz-Cherry
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • The SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme provides a real-time risk assessment of SARS-CoV-2 variants with the potential to affect transmission, virulence and resistance to infection- and vaccine-induced immunity.

    • Marciela M. DeGrace
    • Elodie Ghedin
    • Mehul S. Suthar
    Reviews
    Nature
    Volume: 605, P: 640-652