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Showing 1–11 of 11 results

Advanced filters: Author: Brandon Hirsch Clear advanced filters

The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages

The PI3K–PTEN signalling pathway is a central regulator of metabolic homeostasis. Brunner et al. find that cell-intrinsic PI3K signalling allows adipose tissue macrophages to buffer obesity-induced lipotoxicity by promoting lipid uptake and catabolism.

Julia S. Brunner
Andrea Vogel
Gernot Schabbauer
Research16 Nov 2020
Nature Metabolism

Volume: 2, P: 1427-1442
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
Urbanization, climate and species traits shape mammal communities from local to continental scales

Multi-species occupancy modelling using camera-trap data from 725 sites across 20 North American cities shows how environmental and climate characteristics interact with species traits to influence the effects of urbanization on wildlife communities.

Jeffrey D. Haight
Sharon J. Hall
Jesse S. Lewis
Research04 Sept 2023
Nature Ecology & Evolution

Volume: 7, P: 1654-1666
Genomic evolution and chemoresistance in germ-cell tumours

Genomic analyses show that primary germ-cell tumours are highly enriched for chromosomal reciprocal loss of heterozygosity, mutations in KRAS and have high mitochondrial priming, providing insight into chemosensitivity and the evolution of chemoresistance in this disease.

Amaro Taylor-Weiner
Travis Zack
Eliezer M Van Allen
Research30 Nov 2016
Nature

Volume: 540, P: 114-118
Interface Chemistry of Graphene/Cu Grafted By 3,4,5-Tri-Methoxyphenyl

Gina Ambrosio
Giovanni Drera
Stefania Pagliara
ResearchOpen Access05 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Zuzana Kos
Elvire Roblin
Zsuzsanna Bago-Horvath
ResearchOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-16
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Mohamed Amgad
Elisabeth Specht Stovgaard
Zaheed Husain
ReviewsOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-13
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Khalid El Bairi
Harry R. Haynes
Paul J. Van Diest
ReviewsOpen Access01 Dec 2021
npj Breast Cancer

Volume: 7, P: 1-17
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Jan Hudeček
Leonie Voorwerk
Zsuzsanna Bago-Horvath
ReviewsOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-8