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Showing 1–6 of 6 results
Advanced filters: Author: Brandon J. Jolly Clear advanced filters

  • Comprehensive integration of gene expression with epigenetic features is needed to understand the transition of kidney cells from health to injury. Here, the authors integrate dual single nucleus RNA expression and chromatin accessibility, DNA methylation, and histone modifications to decipher the chromatin landscape of the kidney in reference and adaptive injury cell states, identifying a transcription factor network of ELF3, KLF6, and KLF10 which regulates adaptive repair and maladaptive failed repair.

    • Debora L. Gisch
    • Michelle Brennan
    • Michael T. Eadon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • The GREGoR consortium provides foundational resources and substrates for the future of rare disease genomics.

    • Moez Dawood
    • Ben Heavner
    • Gabrielle C. Villard
    Reviews
    Nature
    Volume: 647, P: 331-342

  • Integrated catalysis can streamline multi-step syntheses in a single reaction vessel to achieve a high degree of control and reduce the waste and cost of chemical processes. In this Primer, Deng et al. discuss the underlying mechanisms of common approaches to integrated catalysis, highlighting recent advances in the field.

    • Shijie Deng
    • Brandon J. Jolly
    • Paula L. Diaconescu
    Reviews
    Nature Reviews Methods Primers
    Volume: 3, P: 1-19