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Showing 1–9 of 9 results
Advanced filters: Author: Brant E. Isakson Clear advanced filters

  • Microglia are involved in debris clearance and synaptic pruning, among other processes. However, their direct interaction with the brain vasculature is less clear. Here, the authors show that capillary-associated microglia (CAMs) regulate vascular tone via PANX1-P2RY12 signalling.

    • Kanchan Bisht
    • Kenneth A. Okojie
    • Ukpong B. Eyo
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The role of myeloid cells in vascular regulation remains incompletely understood. Here, the authors show that microglia are the only myeloid cells that localize to capillaries and that they maintain basal capillary dilatory tone via cyclooxygenase-1 activity.

    • William A. Mills III
    • Niesha A. Savory
    • Ukpong B. Eyo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • This study presents a new model for the regulation of nitric oxide signalling in endothelial cells; the oxidation state of endothelial haemoglobin α, controlled by cytochrome B5 reductase 3, regulates nitric oxide bioactivity and diffusion towards its vascular smooth muscle targets.

    • Adam C. Straub
    • Alexander W. Lohman
    • Brant E. Isakson
    Research
    Nature
    Volume: 491, P: 473-477

  • In mammals, hypoxia causes dilation of small arteries for increased metabolic demand. Keller et al used novel transgenic mice to show alpha hemoglobin in endothelium, once thought only in red blood cells, can regulate hypoxic-mediated dilation.

    • T. C. Stevenson Keller IV
    • Christophe Lechauve
    • Brant E. Isakson
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Endothelial cell activation by inflammation requires extracellular ATP release. Here the authors show that TNF-α induces Src-family kinase-dependent ATP release by Pannexin1 channels in endothelial cells, and that Pannexin1 is required for leukocyte adhesion and emigration into the inflamed tissue.

    • Alexander W. Lohman
    • Igor L. Leskov
    • Brant E. Isakson
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Pannexin-1 ion channels on endothelial cells regulate vascular inflammation and remodeling to mediate aortic aneurysm formation. Pharmacological blockade of Pannexin-1 channels may offer translational therapeutic mitigation of aneurysmal pathology.

    • Amanda C. Filiberto
    • Michael D. Spinosa
    • Ashish K. Sharma
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Izumo and Juno are receptors on sperm and eggs respectively required for fusion, but other factors for sperm-egg fusion are poorly studied. Here, the authors report that phosphatidylserine, found mainly on cells marked for death, is also present on motile sperm, recognized by egg receptors, and is required for sperm-egg fusion.

    • Claudia M. Rival
    • Wenhao Xu
    • Kodi S. Ravichandran
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Apoptotic cells discharge ATP and UTP, which act as 'find-me' signals for phagocytes that in turn engulf dying cells before potentially harmful cellular contents are released. These authors show that the release of ATP and UTP is exclusively by means of the plasma membrane channel pannexin 1, which is opened specifically by caspase activity.

    • Faraaz B. Chekeni
    • Michael R. Elliott
    • Kodi S. Ravichandran
    Research
    Nature
    Volume: 467, P: 863-867