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Showing 1–2 of 2 results
Advanced filters: Author: Breanna Titchen Clear advanced filters

  • While anti-PD-1 therapy can be effective in patients with breast cancer, response varies and is often limited by the development of resistance. Here, the authors investigate molecular determinant of response and resistance using multiomic single nucleus sequencing of longitudinal biopsies taken from breast cancer patients on a phase II clinical trial investigating neoadjuvant chemotherapy and pembrolizumab (anti-PD-1).

    • Jingxin Fu
    • Adrienne G. Waks
    • Eliezer M. Van Allen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Existing methods for identifying differential gene expression signatures for clinical case/control analyses with high throughput sequencing data present various challenges. Here, the authors develop BEANIE, a nonparametric statistical method that outperforms existing approaches for simulated and real-world cancer datasets, revealing biologically and clinically relevant insights.

    • Shreya Johri
    • Kevin Bi
    • Eliezer M. Van Allen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14