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Showing 1–5 of 5 results
Advanced filters: Author: Brendan P. Lucey Clear advanced filters

  • In a bidirectional relationship, the sleep/wake cycle regulates amyloid-β (Aβ) levels and Aβ accumulation then disrupts sleep. A quantitative three-way model now suggests that Aβ impairs memory via its effect on sleep.

    • Brendan P Lucey
    • David M Holtzman
    News & Views
    Nature Neuroscience
    Volume: 18, P: 933-934

  • The past few years have seen the identification of a growing number of risk factors for Alzheimer disease (AD). In this Perspectives article, the authors discuss the evidence for a bidirectional relationship between disrupted sleep patterns and amyloid-β accumulation, and the potential implications for disease progression in AD.

    • Yo-El S. Ju
    • Brendan P. Lucey
    • David M. Holtzman
    Reviews
    Nature Reviews Neurology
    Volume: 10, P: 115-119

  • Paterson and colleagues describe how stable isotope labelling kinetics (SILK) can be used to determine protein production and clearance rates. They highlight the promise of SILK studies for elucidating the role of pathogenic proteins in neurodegenerative diseases, including Alzheimer disease.

    • Ross W. Paterson
    • Audrey Gabelle
    • Randall J. Bateman
    Reviews
    Nature Reviews Neurology
    Volume: 15, P: 419-427

  • To understand if brain interstitial fluid/cerebrospinal fluid (ISF/CSF) exchange, CSF turnover, blood-brain barrier function or proteolysis were affected by aging or the presence of β amyloid plaques, Elbert et al. develop a non-steady state physiological model using MRI-derived brain volumes, stable isotope labeling kinetics of Aβ, and lumbar CSF Aβ concentration. Their model suggests an important role for blood-brain barrier transport and proteolytic degradation of Aβ in the development Alzheimer’s Disease in humans.

    • Donald L. Elbert
    • Bruce W. Patterson
    • Randall J. Bateman
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-13