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Showing 1–4 of 4 results
Advanced filters: Author: Brennen Heames Clear advanced filters

  • While a bioinformatic comparison of de novo genes and synthetic random sequence does not identify a difference in biophysical properties, in vitro expression shows higher solubility for the de novo proteins, suggesting better integration into the cellular system than random sequences.

    • Brennen Heames
    • Filip Buchel
    • Klára Hlouchová
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 7, P: 570-580

  • Analysis of genomes, transcriptomes and proteomes from recently diverged rice species provides mechanistic insight into the process of de novo gene origination.

    • Erich Bornberg-Bauer
    • Brennen Heames
    News & Views
    Nature Ecology & Evolution
    Volume: 3, P: 524-525

  • Previous work identified goddard as a putative de novo evolved gene in Drosophila melanogaster. Here, the authors characterize the structure and function of the Goddard protein in D. melanogaster, and they infer its ancestral and extant structures across the Drosophila genus.

    • Andreas Lange
    • Prajal H. Patel
    • Erich Bornberg-Bauer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Insertions/Deletions (InDels) remain an untapped source of protein diversity in laboratory evolution. The method TRIAD generates libraries of random variants with short in-frame InDels using transposons, allowing a comparison of their evolutionary potential with widely-used point mutant libraries.

    • Stephane Emond
    • Maya Petek
    • Florian Hollfelder
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14