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Showing 1–3 of 3 results
Advanced filters: Author: Brett E. Houk Clear advanced filters

  • Treatment of KRASG12C-mutant cancer cells with the KRAS(G12C) inhibitor AMG 510 leads to durable response in mice, and anti-tumour activity in patients suggests that AMG 510 could be effective in patients for whom treatments are currently lacking.

    • Jude Canon
    • Karen Rex
    • J. Russell Lipford
    Research
    Nature
    Volume: 575, P: 217-223

  • Although general inhibitors of the ubiquitin-proteasome system have been reported, compounds targeting specific ubiquitylation enzymes should be beneficial in clinical applications and basic research. Aghajan et al. present an inhibitor of the yeast SCFMet30 E3 ligase that prevents the binding of the Met30 F-box protein to the core ligase complex.

    • Mariam Aghajan
    • Nao Jonai
    • Jing Huang
    Research
    Nature Biotechnology
    Volume: 28, P: 738-742

  • Ageing in the worm Caenorhabditis elegans is shown to be delayed by supplementation with α-ketoglutarate, an effect that is probably mediated by ATP synthase—which is identified as a direct target of α-ketoglutarate—and target of rapamycin (TOR).

    • Randall M. Chin
    • Xudong Fu
    • Jing Huang
    Research
    Nature
    Volume: 510, P: 397-401