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Showing 1–4 of 4 results
Advanced filters: Author: Brett H. Pogostin Clear advanced filters

  • The mechanism of collagen heterotrimer folding is difficult to recapitulate synthetically. Now an ABC collagen mimetic heterotrimer has been designed that employs pairwise amino acid interactions, validated by X-ray crystallography, to promote composition- and register-specific assembly. The high specificity of its assembly leads to an increased rate of folding compared with similar collagen heterotrimers.

    • Carson C. Cole
    • Douglas R. Walker
    • Jeffrey D. Hartgerink
    Research
    Nature Chemistry
    Volume: 16, P: 1698-1704

  • A peptide display method was developed, revealing that a kinase important for infection by Salmonella and related pathogens detects specific human antimicrobial peptides, possibly reflecting bacterial adaptation to distinct host locations.

    • Kathryn R. Brink
    • Maxwell G. Hunt
    • Jeffrey J. Tabor
    Research
    Nature Chemical Biology
    Volume: 19, P: 451-459

  • Improving medication adherence is recognized as one of the most impactful and cost-effective strategies for improving the health of the general population. Here, Baryakova and colleagues assess the potential of next-generation drug delivery systems to mitigate many common impediments to adherence and discuss the impact that drug delivery systems have had across different disease types.

    • Tsvetelina H. Baryakova
    • Brett H. Pogostin
    • Kevin J. McHugh
    Reviews
    Nature Reviews Drug Discovery
    Volume: 22, P: 387-409