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Showing 1–8 of 8 results
Advanced filters: Author: Brian B. Tuch Clear advanced filters

  • A detailed molecular analysis of related yeast species shows that progressively opposed genetic logics can evolve while resulting in a conserved phenotypic output:mating-type determination. This is the first clear demonstration of the 'genetic drift' principle at a molecular level.

    • Annie E. Tsong
    • Brian B. Tuch
    • Alexander D. Johnson
    Research
    Nature
    Volume: 443, P: 415-420

  • As part of the modENCODE initiative, which aims to characterize functional DNA elements in D. melanogaster and C. elegans, this study uses RNA-Seq, tiling microarrays and cDNA sequencing to explore the transcriptome in 30 distinct developmental stages of the fruitfly. Among the results are scores of new genes, coding and non-coding transcripts, as well as splicing and editing events.

    • Brenton R. Graveley
    • Angela N. Brooks
    • Susan E. Celniker
    Research
    Nature
    Volume: 471, P: 473-479

  • Species that are evolutionary distinct and have geographically narrow or isolated distributions may be in particular need of conservation. Here, the authors identify global patterns of tree phylogenetic endemism and their linkages with climate and land use, and estimate future trends.

    • Wen-Yong Guo
    • Josep M. Serra-Diaz
    • Jens-Christian Svenning
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Wenzell et al. developed a massively parallel screening platform to interrogate the sensitivity of signal peptides (SPs) to Sec61 inhibitors. The platform revealed how distinct inhibitors achieve sequence-dependent SP discrimination.

    • Nicole A. Wenzell
    • Brian B. Tuch
    • Jack Taunton
    Research
    Nature Chemical Biology
    Volume: 20, P: 1154-1163

  • Previous whole-transcriptome analysis by RNA-Seq required hundreds of thousands of cells or microgram amounts of RNA. A modification of the cDNA library preparation method now allows unbiased capture of the majority of genes expressed in a single blastomere and oocyte. cDNA sequencing on the SOLiD platform facilitates the quantitative analysis of the transcriptome complexity in a single cell.

    • Fuchou Tang
    • Catalin Barbacioru
    • M Azim Surani
    Research
    Nature Methods
    Volume: 6, P: 377-382

  • A subset of patients treated with selective TRK inhibitors (including the newly approved larotrectinib) develop off-target resistance mediated by genomic acquisition of MAPK pathway-activating alterations, and may benefit from combined targeted therapy.

    • Emiliano Cocco
    • Alison M. Schram
    • Maurizio Scaltriti
    Research
    Nature Medicine
    Volume: 25, P: 1422-1427

  • How new phenotypes can be introduced during evolution without losses of fitness remains largely unexplained at the molecular level. By comparing the molecular details of a well known process — mating type determination — across a large diversity of yeast species, the network rewiring event of the intercalation of a new level of gene transcription control into an ancient regulatory circuit is shown, which allowed for the creation of a new phenotype — taking food availability into account when deciding to mate.

    • Lauren N. Booth
    • Brian B. Tuch
    • Alexander D. Johnson
    Research
    Nature
    Volume: 468, P: 959-963

  • Epistatic interactions, whereby a mutation's effect is contingent on another mutation, have been shown to constrain evolution within single proteins, and how such interactions arise in gene regulatory networks has remained unclear; here the appearance of pheromone-response regulator binding sites in the regulatory DNA of the a-specific genes of Saccharomyces cerevisiae are shown to have required specific changes in a second pathway during the evolution from its common ancestor with Candida albicans.

    • Trevor R. Sorrells
    • Lauren N. Booth
    • Alexander D. Johnson
    Research
    Nature
    Volume: 523, P: 361-365