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Showing 1–4 of 4 results
Advanced filters: Author: Brian D. Hamman Clear advanced filters

  • In molecular spintronics, the spin state of a molecule may be switched by changing the molecular structure. Here, the spin of a single-molecule magnet is switched by applying an electric current using a scanning tunnelling microscope, which may aid in information coding at the single-molecule level.

    • Tadahiro Komeda
    • Hironari Isshiki
    • Masahiro Yamashita
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-7

  • PROTACs enable targeted protein degradation by recruiting an E3 ligase to a specific substrate but the determinants of selectivity are not fully understood. Here, the authors show that varying the linker between warhead and E3 ligand and the orientation of the E3 ligase allow tuning PROTAC selectivity toward different p38 isoforms.

    • Blake E. Smith
    • Stephen L. Wang
    • Craig M. Crews
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • SMARCA2 has been identified as a synthetic lethal target in SMARCA4 mutated tumors, however, homology between the two has hindered the development of selective SMARCA2 inhibitors. Here, the authors synthesize a proteolysis targeting chimera (PROTAC) capable of SMARCA2 specific degradation and demonstrate its utility in the treatment of SMARCA4 mutated tumors.

    • Jennifer Cantley
    • Xiaofen Ye
    • Robert L. Yauch
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14