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Nature Communications (2)

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Advanced filters: Author: Brian H. Carrick Clear advanced filters

A higher order PUF complex is central to regulation of C. elegans germline stem cells

PUF proteins, conserved stem cell regulators, maintain germline stem cells with partner proteins in nematodes. Here, authors discover a complex of two FBF-2 PUF proteins and partner LST-1 that represses target mRNA via adjacent regulatory elements.

Chen Qiu
Sarah L. Crittenden
Traci M. Tanaka Hall
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer

Tumour evolution and heterogeneity in high grade serous ovarian cancer (HGSOC) remains poorly characterised. Here, the authors investigate the genomic landscape of HGSOC and reveal two distinct evolutionary trajectories associated with clinical outcomes.

Ailith Ewing
Alison Meynert
Colin A. Semple
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-14

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A higher order PUF complex is central to regulation of C. elegans germline stem cells

Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer

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