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Showing 1–6 of 6 results

Advanced filters: Author: Brian Houck-Loomis Clear advanced filters

An equilibrium-dependent retroviral mRNA switch regulates translational recoding

The NMR structure of the murine leukaemia virus recoding translational signal is determined, giving insight into the mechanism of read-through in retroviruses.

Brian Houck-Loomis
Michael A. Durney
Victoria M. D’Souza
Research27 Nov 2011
Nature

Volume: 480, P: 561-564
Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring

A new approach for whole-genome sequencing of plasma circulating tumor DNA allows for dynamic monitoring of disease burden and ultra-sensitive detection of minimal residual disease.

Asaf Zviran
Rafael C. Schulman
Dan A. Landau
Research01 Jun 2020
Nature Medicine

Volume: 26, P: 1114-1124
Resistance to TRK inhibition mediated by convergent MAPK pathway activation

A subset of patients treated with selective TRK inhibitors (including the newly approved larotrectinib) develop off-target resistance mediated by genomic acquisition of MAPK pathway-activating alterations, and may benefit from combined targeted therapy.

Emiliano Cocco
Alison M. Schram
Maurizio Scaltriti
Research12 Aug 2019
Nature Medicine

Volume: 25, P: 1422-1427
Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries

A synthetic library of nucleosomes, each with a DNA-barcode characteristic for a defined post-translational modification (PTM), is used to probe PTM-based recruitment and modulation of histone mark readers and writers.

Uyen T T Nguyen
Lenka Bittova
Tom W Muir
Research06 Jul 2014
Nature Methods

Volume: 11, P: 834-840
Simultaneous epitope and transcriptome measurement in single cells

Using established high-throughput single-cell RNA-seq platforms, CITE-seq combines highly multiplexed, antibody-based protein marker quantification with unbiased transcriptome profiling for thousands of single cells.

Marlon Stoeckius
Christoph Hafemeister
Peter Smibert
Research31 Jul 2017
Nature Methods

Volume: 14, P: 865-868
ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance

Antonio Strillacci
Pasquale Sansone
Jacqueline Bromberg
ResearchOpen Access23 Aug 2022
npj Breast Cancer

Volume: 8, P: 1-16