Biallelic inactivation of the VHL tumour suppressor gene is a hallmark of Clear cell renal cell carcinoma (ccRCC). Here the authors perform genome-wide CRISPR/Cas9 screening to identify that loss of Core Binding Factor β (CBF-β), a component of RUNX transcription factor complexes, is synthetically lethal in VHL-deficient ccRCC tumour models.
- James A. C. Bertlin
- Tekle Pauzaite
- James A. Nathan
