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Detecting organelle-specific activity of potassium channels with a DNA nanodevice

A potassium activity reporter detects organelle-specific channel function.

Palapuravan Anees
Anand Saminathan
Yamuna Krishnan
Research21 Sept 2023
Nature Biotechnology

Volume: 42, P: 1065-1074
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome

Type 2 Long QT syndrome is a cardiac disease associated with hundreds of individual mutations within the Kv11.1 potassium channel. Here, the authors systematically investigate the trafficking defects associated with different types of Kv11.1 mutations and to what extent they can be corrected pharmacologically.

Corey L. Anderson
Catherine E. Kuzmicki
Craig T. January
Research24 Nov 2014
Nature Communications

Volume: 5, P: 1-13
Dim light at night unmasks sex-specific differences in circadian and autonomic regulation of cardiovascular physiology

Restricted feeding to the dim light at night restores disrupted day-night autonomic and cardiovascular rhythms but not activity in male and female mice.

Abhilash Prabhat
Dema Sami
Brian P. Delisle
ResearchOpen Access27 Sept 2024
Communications Biology

Volume: 7, P: 1-14
Prediction of mortality from 12-lead electrocardiogram voltage data using a deep neural network

By using data from electrocardiograms, a deep learning algorithm outperforms traditional risk scores in predicting death over the course of the next year and identifies at-risk individuals with seemingly normal electrocardiograms.

Sushravya Raghunath
Alvaro E. Ulloa Cerna
Brandon K. Fornwalt
Research11 May 2020
Nature Medicine

Volume: 26, P: 886-891
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy

Quantitative global phosphotyrosine proteomics of two mouse models of hypertrophic cardiomyopathy reveals that tyrosine kinase inhibitors may be a future therapeutic approach for treating hypertrophic cardiomyopathy.

Mingguo Xu
Kevin C. Bermea
Genaro A. Ramirez-Correa
ResearchOpen Access15 Nov 2022
Communications Biology

Volume: 5, P: 1-17
A rapid solubility assay of protein domain misfolding for pathogenicity assessment of rare DNA sequence variants

Corey L. Anderson
Tim C. Routes
Timothy J. Kamp
Research01 Jun 2020
Genetics in Medicine

Volume: 22, P: 1642-1652
Electronic health record phenotype in subjects with genetic variants associated with arrhythmogenic right ventricular cardiomyopathy: a study of 30,716 subjects with exome sequencing

Christopher M Haggerty
Cynthia A James
Brandon K Fornwalt
Research04 May 2017
Genetics in Medicine

Volume: 19, P: 1245-1252

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