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Showing 1–19 of 19 results
Advanced filters: Author: Briana R. Dye Clear advanced filters

  • DNA G-quadruplexes can adopt a variety of secondary structures, but it is challenging to identify and classify them quickly. Multivariate analysis of different fluorescence enhancements—generated from an arrayed suite of synthetic hosts and cationic dyes—enables discrimination between G-quadruplex structures of identical length and similar topological types.

    • Junyi Chen
    • Briana L. Hickey
    • Wenwan Zhong
    Research
    Nature Chemistry
    Volume: 13, P: 488-495

  • Gut epithelium generated electrical potentials drive differential localization of enterobacteria, promoting Salmonella tropism for the follicle-associated epithelium while Escherichia coli localize to villi.

    • Yaohui Sun
    • Fernando Ferreira
    • Min Zhao
    ResearchOpen Access
    Nature Microbiology
    Volume: 9, P: 2653-2665

  • Delivering therapeutics to the brain is challenging because of the hard-to-cross blood–brain barrier. Here, the authors show that HER3, which is expressed on the surface of many metastatic tumours, is associated with the brain endothelium and can drive accumulation of HER3-targeted nanoparticles within the brain, for therapy against HER3-positive tumours.

    • Felix Alonso-Valenteen
    • Simoun Mikhael
    • Lali K. Medina-Kauwe
    ResearchOpen Access
    Nature Nanotechnology
    Volume: 20, P: 683-696

  • The Clostridium difficile virulence factors TcdA and TcdB contain a glucosyltransferase domain (GTD), which has both glucohydrolase (GH) and glucosyltransferase (GT) activities. Here, the authors characterize the transition state features of the TcdA and TcdB GH reactions by measuring kinetic isotope effects and they identify two transition state analogues, isofagomine and noeuromycin that inhibit TcdA and TcdB. They also present the crystal structures of TcdB-GTD bound to these inhibitors and the reaction product UDP.

    • Ashleigh S. Paparella
    • Briana L. Aboulache
    • Vern L. Schramm
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • In a mouse model of breast cancer, a low-protein diet induces engulfment activities and mTORC1 signalling in tumour-associated macrophages to suppress engulfment-dependent mTORC1 signalling in MYC-overexpressing cancer cells through cell competition, serving as an innate immune defence mechanism to slow tumour growth.

    • Xian Zhang
    • Shun Li
    • Ming O. Li
    Research
    Nature
    Volume: 619, P: 616-623

  • The cytokine IL-18 can drive autoantibody production. Karlsson and colleagues show that such responses are limited by a three-way cellular interaction whereby splenic neutrophils activate both B cells and invariant natural killer T cells but the activated B cells are killed by FasL+ invariant natural killer T cells.

    • Thomas Hägglöf
    • Saikiran K Sedimbi
    • Mikael C I Karlsson
    Research
    Nature Immunology
    Volume: 17, P: 1407-1414

  • We provide an updated protocol for image-based profiling with Cell Painting. A detailed procedure, with standardized conditions for the assay, is presented, along with a comprehensive description of parameters to be considered when optimizing the assay.

    • Beth A. Cimini
    • Srinivas Niranj Chandrasekaran
    • Anne E. Carpenter
    Protocols
    Nature Protocols
    Volume: 18, P: 1981-2013

  • The SARS-CoV-2 Alpha variant suppresses innate immune responses more effectively than isolates of first-wave SARS-CoV-2, and this is a result of mutations outside of the spike coding region that lead to upregulation of viral innate immune antagonists.

    • Lucy G. Thorne
    • Mehdi Bouhaddou
    • Nevan J. Krogan
    ResearchOpen Access
    Nature
    Volume: 602, P: 487-495

  • Ovarian cancer cells often metastasize to the peritoneal cavity, forming spheroid-like structures and promoting a highly immunosuppressive tumor microenvironment. Here, the authors show that the ubiquitin ligase UBR5 is required for ovarian cancer growth and metastasis, sustaining spheroid formation and the infiltration of immunosuppressive tumor associated macrophages.

    • Mei Song
    • Oladapo O. Yeku
    • Xiaojing Ma
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • The CPJUMP1 Resource comprises Cell Painting images and profiles of 75 million cells treated with hundreds of chemical and genetic perturbations. The dataset enables exploration of their relationships and lays the foundation for the development of advanced methods to match perturbations.

    • Srinivas Niranj Chandrasekaran
    • Beth A. Cimini
    • Anne E. Carpenter
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 1114-1121

  • CAR T cells targeting PSMA and engineered to be resistant to immunosuppressive TGFβ signaling exhibit dose-dependent toxicity and expansion following infusion, with some transient antitumor activity, in patients with metastatic castration-resistant prostate cancer

    • Vivek Narayan
    • Julie S. Barber-Rotenberg
    • Naomi B. Haas
    Research
    Nature Medicine
    Volume: 28, P: 724-734

  • Rachel Meyer and colleagues use whole-genome resequencing of 93 African rice landraces to generate a SNP map used for population analysis and a genome-wide association study for salt tolerance traits. They find 11 significant loci, some with signatures of positive selection, and evidence for a population bottleneck beginning around 15,000 years ago.

    • Rachel S Meyer
    • Jae Young Choi
    • Michael D Purugganan
    Research
    Nature Genetics
    Volume: 48, P: 1083-1088

  • Human pluripotent stem cells are differentiated into ventral–anterior foregut spheroids and then to lung organoids, resembling the bronchi and surrounding mesenchyme of the developing human airway, or bud tip progenitor organoids.

    • Alyssa J. Miller
    • Briana R. Dye
    • Jason R. Spence
    Protocols
    Nature Protocols
    Volume: 14, P: 518-540