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Showing 1–8 of 8 results
Advanced filters: Author: Britta Trappmann Clear advanced filters

  • Current tissue engineering strategies lack materials that promote angiogenesis. Here the authors develop a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfusable lumens to determine the material properties that regulate angiogenesis.

    • Jifeng Liu
    • Hongyan Long
    • Britta Trappmann
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The fabrication of vascularized 3D tissues requires an understanding of how material properties govern endothelial cell invasion into the surrounding matrix. Here the authors integrate a non-swelling synthetic hydrogel with a microfluidic device to study chemokine gradient-driven angiogenic sprouting and find that matrix degradability modulates the collectivity of cell migration.

    • Britta Trappmann
    • Brendon M. Baker
    • Christopher S. Chen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • The spreading and differentiation of stem cells is influenced by the mechanical properties—in particular by the stiffness—of the extracellular matrix. Now, experiments on epidermal stem cells cultured on substrates with a covalently attached collagen coating show that stem cells sense the stiffness of the substrate through the anchoring density of collagen fibres.

    • Britta Trappmann
    • Julien E. Gautrot
    • Wilhelm T. S. Huck
    Research
    Nature Materials
    Volume: 11, P: 642-649

  • Pericytes surround endothelial tubules and help maintain the integrity of blood vessels. Here the authors show that pericytes regulate lung morphogenesis via paracrine signalling controlled by components of the Hippo pathway.

    • Katsuhiro Kato
    • Rodrigo Diéguez-Hurtado
    • Ralf H. Adams
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14