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Communications Biology (1)

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Inhibition of complement C3 prevents osteoarthritis progression in guinea pigs by blocking STAT1 activation

Osteoarthritis (OA) affects over 500 million adults worldwide. Signal transducer and activator of transcription 1 can increase complement C3 expression after IL-1β stimulation, and STAT1 inhibition can prevent OA pathogenesis in guinea pigs.

Jen X. Xu
Frank Z. Xu
Yuri K. Peterson
ResearchOpen Access27 Mar 2024
Communications Biology

Volume: 7, P: 1-11

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Inhibition of complement C3 prevents osteoarthritis progression in guinea pigs by blocking STAT1 activation

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