Nature Search

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

Meningeal lymphatic drainage can affect the microglial inflammatory response and anti-amyloid-β immunotherapy in mouse models of Alzheimer’s disease.

Sandro Da Mesquita
Zachary Papadopoulos
Jonathan Kipnis
Research28 Apr 2021
Nature

Volume: 593, P: 255-260
Area postrema neurons mediate interleukin-6 function in cancer cachexia

Elevation of IL-6 during cancer progression has been shown to drive cancer cachexia, however, while brain dysfunction has been reported, the underlying mechanism is unclear. Here, the authors identify neurons in the area postrema as a mediator of peripheral IL-6 in preclinical models of cancer cachexia.

Qingtao Sun
Daniëlle van de Lisdonk
Bo Li
ResearchOpen Access01 Jun 2024
Nature Communications

Volume: 15, P: 1-19
Small GTP-binding protein associated with Golgi cisternae

Bruno Goud
Ahmed Zahraoui
Jaakko Saraste
Research07 Jun 1990
Nature

Volume: 345, P: 553-556
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

A divalent siRNA architecture enables sustained silencing of gene expression in deep regions of the brain.

Julia F. Alterman
Bruno M. D. C. Godinho
Anastasia Khvorova
Research02 Aug 2019
Nature Biotechnology

Volume: 37, P: 884-894
Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish

Disruptions to the ER-Golgi network can lead to neurodevelopmental disorders, though our understanding of these Golgipathies remains incomplete. Here Lauri, Tartaglia and colleagues show that ARF3 mutations cause a rare pediatric neurological disorder and perform detailed molecular characterization in fish.

Giulia Fasano
Valentina Muto
Marco Tartaglia
ResearchOpen Access11 Nov 2022
Nature Communications

Volume: 13, P: 1-29
Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3

The E2-like enzyme Atg3 conjugates phosphatidylethanolamine (PE) to Atg8 to facilitate its membrane association and promote autophagosome maturation. Melia and colleagues report that Atg3 preferentially associates in vitro with highly curved, PE-enriched membranes, such as the isolation membrane of a nascent autophagosome, thus ensuring access to a local supply of PE.

Sangeeta Nath
Julia Dancourt
Thomas J. Melia
Research20 Apr 2014
Nature Cell Biology

Volume: 16, P: 415-424
Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum

Andreas Girod
Brian Storrie
Rainer Pepperkok
Research12 Oct 1999
Nature Cell Biology

Volume: 1, P: 423-430
Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

The authors show that traumatic brain injury can induce peroxidation of cardiolipin, leading to accumulation of numerous oxygenated species and the induction of neuronal cell death. This accumulation of cardiolipin and the associated toxicity can be ameliorated by mitochondria-targeted delivery of an electron scavenger.

Jing Ji
Anthony E Kline
Hülya Bayır
Research26 Aug 2012
Nature Neuroscience

Volume: 15, P: 1407-1413
Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

Denervation of muscle fibres induces muscle atrophy, via mechanisms that remain unclear. Here, the authors show that binding of acetylcoline to its receptor at the neuromuscular junction represses the expression of connexins 43 and 45, which promote atrophy, and is sufficient to prevent denervation-induced loss of myofibre mass.

Bruno A. Cisterna
Aníbal A. Vargas
Juan C. Sáez
ResearchOpen Access26 Feb 2020
Nature Communications

Volume: 11, P: 1-13
Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers

Dagmar Zeuschner
Willie J.C. Geerts
Judith Klumperman
Research12 Mar 2006
Nature Cell Biology

Volume: 8, P: 377-383
Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes

M N Loviglio
M Leleu
A Reymond
ResearchOpen Access31 May 2016
Molecular Psychiatry

Volume: 22, P: 836-849

Search

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

Area postrema neurons mediate interleukin-6 function in cancer cachexia

Small GTP-binding protein associated with Golgi cisternae

A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish

Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3

Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum

Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers

Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes

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