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Showing 1–5 of 5 results
Advanced filters: Author: Bruno Hudry Clear advanced filters

  • Active regulation of chirality, or handedness, is crucial for life. Here, the authors describe assays to characterise proteome chirality in vivo and show that errors degrade enzyme activity triggering tumour formation and reduced lifespan.

    • Agnes Banreti
    • Shayon Bhattacharya
    • Stéphane Noselli
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • How cellular metabolism is connected to differentiation remains poorly understood. Here the authors report a regulatory cascade in which circulating citrate regulates sperm production by controlling protein stability via a specific protein post-translational modification.

    • Charlotte M. François
    • Thomas Pihl
    • Bruno Hudry
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • While hormonal signals derived from sex organs are seen as the main contributors to sex differences, the global role of cellular sex remains poorly understood. Here, the authors show that every cell converts the intrinsic presence of sex chromosomes into the active production of a sex determinant.

    • Chloé Hérault
    • Thomas Pihl
    • Bruno Hudry
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Studying Drosophila melanogaster Y chromosomes with variable levels of heterochromatin generated using genome editing, the authors show that while different Y chromosomes could disrupt gene silencing on other chromosomes, they did not affect sexual dimorphism in longevity.

    • Rénald Delanoue
    • Charlène Clot
    • Bruno Hudry
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 7, P: 1245-1256

  • Reversible, cell-intrinsic mechanisms that depend on a new sex differentiation pathway act in adult somatic cells of the Drosophila intestine to govern sex-specific differences in organ size, plasticity during reproduction, and response to tumorigenic insults.

    • Bruno Hudry
    • Sanjay Khadayate
    • Irene Miguel-Aliaga
    Research
    Nature
    Volume: 530, P: 344-348