Nature Search

Radial deformation of carbon nanotubes by van der Waals forces

Rodney S. Ruoff
J. Tersoff
Bryan Chan
Research05 Aug 1993
Nature

Volume: 364, P: 514-516
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
m⁶A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

Liu et al. show that reduced m⁶A mRNA methylation in endometrial cancer is oncogenic. Mechanistically, the AKT pathway is activated in these tumours due to altered expression of AKT regulators carrying m⁶A on their transcripts.

Jun Liu
Mark A. Eckert
Chuan He
Research27 Aug 2018
Nature Cell Biology

Volume: 20, P: 1074-1083
Initiation complex dynamics direct the transitions between distinct phases of early HIV reverse transcription

Reverse transcriptase is an essential enzyme for HIV replication. Single-molecule studies reveal for the first time the structural dynamics of the reverse transcription initiation complex in real time. Reverse transcriptase can bind its tRNA–vRNA substrate in two opposite orientations and flip between these two states.

Shixin Liu
Bryan T Harada
Xiaowei Zhuang
Research21 Nov 2010
Nature Structural & Molecular Biology

Volume: 17, P: 1453-1460
Author Correction: m⁶A RNA modifications are measured at single-base resolution across the mammalian transcriptome

Lulu Hu
Shun Liu
Chuan He
Amendments and Corrections30 Nov 2022
Nature Biotechnology

Volume: 41, P: 150
Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution

Pseudouridine sites in mRNA are detected at base resolution and functionally investigated.

Qing Dai
Li-Sheng Zhang
Chuan He
ResearchOpen Access27 Oct 2022
Nature Biotechnology

Volume: 41, P: 344-354
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
m⁶A RNA modifications are measured at single-base resolution across the mammalian transcriptome

m⁶A-SAC-seq uses chemical labeling to quantify m⁶A at single-base resolution in the mammalian transcriptome.

Lulu Hu
Shun Liu
Chuan He
Research14 Mar 2022
Nature Biotechnology

Volume: 40, P: 1210-1219
Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution

CAP-C uses multifunctional DNA crosslinkers of defined sizes to increase resolution and signal-to-noise in chromosome conformation capture experiments.

Qiancheng You
Anthony Youzhi Cheng
Chuan He
Research24 Aug 2020
Nature Biotechnology

Volume: 39, P: 225-235
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing

Zhang et al. identify ALKBH7 as the demethylase of mitochondrial pre-tRNAs that regulates nascent mitochondrial RNA processing and translation. ALKBH7 loss impairs mitochondrial functions including fatty acid oxidation, leading to obesity.

Li-Sheng Zhang
Qing-Ping Xiong
Chuan He
Research12 Jul 2021
Nature Cell Biology

Volume: 23, P: 684-691
Making your mark on DNA

Understanding the biological roles of modifications to DNA, RNA and proteins is critical to revealing how cells regulate gene expression in development and disease. Two papers now present a combination of new tools and discoveries that could enable biologists and chemical biologists to better study epigenetic regulation in mammals.

Bryan T. Harada
Chuan He
News & Views24 Oct 2017
Nature Chemistry

Volume: 9, P: 1040-1042
Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA

A nucleosome-spacing mechanism for human ATP-dependent chromatin assembly and remodelling factor (ACF).

William L. Hwang
Sebastian Deindl
Xiaowei Zhuang
Research29 Jun 2014
Nature

Volume: 512, P: 213-217
NSAIDs disrupt intestinal homeostasis by suppressing macroautophagy in intestinal epithelial cells

Ana M. Chamoun-Emanuelli
Laura K. Bryan
Canaan M. Whitfield-Cargile
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-15
The death effector domain protein family

Bryan C Barnhart
Justine C Lee
Marcus E Peter
Reviews24 Nov 2003
Oncogene

Volume: 22, P: 8634-8644

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