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Showing 1–7 of 7 results
Advanced filters: Author: Bryce Kille Clear advanced filters

  • CLASSIC is a high-throughput genetic profiling platform that combines long- and short-read next-generation-sequencing modalities to quantitatively assess pools of constructs of arbitrary length containing diverse genetic part compositions.

    • Kshitij Rai
    • Ronan W. O’Connell
    • Caleb J. Bashor
    Research
    Nature
    P: 1-10

  • Here the authors report asperigimycins, fungal ribosomally synthesized and post-translationally modified peptides with a heptacyclic scaffold. After chemically modifying them for nanomolar anticancer activity, CRISPR screening identifies SLC46A3 as a key transporter for their uptake in cells.

    • Qiuyue Nie
    • Fanglong Zhao
    • Xue Gao
    Research
    Nature Chemical Biology
    Volume: 21, P: 1938-1947

  • Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evolutionary comparisons.

    • DongAhn Yoo
    • Arang Rhie
    • Evan E. Eichler
    ResearchOpen Access
    Nature
    Volume: 641, P: 401-418

  • Tiled amplicon sequencing is an essential tool for tracking the spread and evolution of pathogens, including SARS-CoV-2, however existing methods for tiled amplicon design require slow and costly downstream manual optimization. Here the authors present Olivar, a first step towards fully automated, variant-aware design of tiled amplicons for pathogen genomes.

    • Michael X. Wang
    • Esther G. Lou
    • Todd J. Treangen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Tracking low frequency intra-host variants has helped understanding within-host viral population dynamics and transmission. Precise tracking, however, depends partially on the error rate of the sequencing platforms used. Here, Liu et al. present Variabel, a method to rescue low frequency intra-host variants from Oxford Nanopore Technologies (ONT) platforms and validate their approach on Ebola virus, norovirus, and SARS-CoV-2 datasets.

    • Yunxi Liu
    • Joshua Kearney
    • Todd J. Treangen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9