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Showing 1–9 of 9 results
Advanced filters: Author: Bryce W. Carey Clear advanced filters

  • Finley et al. show that Brd4 is dispensable for self-renewal and pluripotency in murine embryonic stem cells (ESCs). In metastable ESCs, Brd4 independence can be achieved by increasing the expression of the pluripotency transcription factors Oct4, Sox2 and Nanog as long as Tet1/2 are present.

    • Lydia W. S. Finley
    • Santosha A. Vardhana
    • Craig B. Thompson
    Research
    Nature Cell Biology
    Volume: 20, P: 565-574

  • The James Webb Space Telescope has detected water ice in the cold debris disk (analogous to the Kuiper belt) around the star HD 181327.

    • Chen Xie
    • Christine H. Chen
    • Jarron M. Leisenring
    Research
    Nature
    Volume: 641, P: 608-611

  • The generation of induced pluripotent stem cells might be improved by replacing the reprogramming transgenes with small molecules. To provide cells suitable for small-molecule screening, Markoulaki et al. segregate the transgenes Oct4, Sox2, Klf4 and c-Myc through breeding, creating mice carrying all possible combinations of the four factors.

    • Styliani Markoulaki
    • Jacob Hanna
    • Rudolf Jaenisch
    Research
    Nature Biotechnology
    Volume: 27, P: 169-171

  • Mouse strains in which three or four cellular reprogramming factors are expressed from a defined genomic locus are presented. They will enable studies of reprogramming in multiple cell types as well as facilitate comparisons between induced pluripotent stem cells and embryonic stem cells. Also in this issue, a paper from Stadtfeld et al. presents related tools.

    • Bryce W Carey
    • Styliani Markoulaki
    • Rudolf Jaenisch
    Research
    Nature Methods
    Volume: 7, P: 56-59

  • If deprived of exogenous glutamine, naive mouse embryonic stem cells are shown to be capable of generating the amino acid from other sources to enable their proliferation; the stem cells use glutamine and glucose catabolism to maintain a high level of intracellular α-ketoglutarate and promote demethylation of chromatin and ensure sufficient expression of pluripotency-associated genes.

    • Bryce W. Carey
    • Lydia W. S. Finley
    • Craig B. Thompson
    Research
    Nature
    Volume: 518, P: 413-416

  • Glutamine is a major fuel for proliferating cells. Here the authors show that reduced dependence on exogenous glutamine is a generalizable feature of self-renewing pluripotent stem cells that can be exploited to select for mouse and human pluripotent stem cells with high self-renewal potential.

    • Santosha A. Vardhana
    • Paige K. Arnold
    • Lydia W. S. Finley
    Research
    Nature Metabolism
    Volume: 1, P: 676-687

  • This study uses chromatin marks in four mouse cell types to identify ∼1,600 large multi-exonic transcriptional units that do not overlap known protein-coding loci and are highly conserved. Putative functions are assigned to each of these large intervening non-coding RNAs, which range from ES pluripotency to cell proliferation.

    • Mitchell Guttman
    • Ido Amit
    • Eric S. Lander
    Research
    Nature
    Volume: 458, P: 223-227