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Showing 1–2 of 2 results
Advanced filters: Author: Bujinlkham Buyantogtokh Clear advanced filters

  • Lipids are complex molecules crucial for life. The authors developed MS-DIAL 5, a tool that enhances in-depth structure elucidations and the spatial mapping of lipidome. Using advanced techniques, they uncovered new insights into the biosynthetic pathway of eye-specific phosphatidylcholines.

    • Hiroaki Takeda
    • Yuki Matsuzawa
    • Hiroshi Tsugawa
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Oxygen attachment dissociation (OAD) has been limited to positive-ion mode, hindering comprehensive lipidomics analysis. Here, the authors extend OAD to negative-ion mode, introducing OAciD for simultaneous CID and OAD fragment acquisition, enabling detailed C=C positional analysis and revealing brain region-specific lipidome variations, with implications for understanding lipid distribution in neurological contexts.

    • Hiroaki Takeda
    • Mami Okamoto
    • Hiroshi Tsugawa
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-13