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Showing 1–7 of 7 results
Advanced filters: Author: Bulent O. Yildiz Clear advanced filters

  • This study identifies four distinct polycystic ovary syndrome (PCOS) subtypes using unsupervised clustering analysis on data from 11,908 women and validated across five diverse cohorts. The subtypes show unique clinical features and suggest that subtype-specific management could enhance treatment precision for PCOS.

    • Xueying Gao
    • Shigang Zhao
    • Zi-Jiang Chen
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 4214-4224

  • Oral contraceptives are the mainstay of long-term PCOS treatment, but have potential adverse cardiometabolic effects. In a randomized controlled trial comparing oral contraceptive use and structured exercise in women with PCOS and overweight on a calorie-restricted diet, androgen excess was ameliorated with oral contraceptive use and structured exercise improved markers of cardiometabolic risk.

    • Bulent O. Yildiz
    News & Views
    Nature Reviews Endocrinology
    Volume: 12, P: 438-440

  • Hirsutism is a common presenting complaint in women of reproductive age and can cause significant psychological distress and embarrassment. This article describes the case of a 20-year-old woman in whom hirsutism was caused by polycystic ovary syndrome, and illustrates the clinical assessment, investigations and management of a patient with hirsutism.

    • Bulent O Yildiz
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 4, P: 294-300

  • Over the past two decades, polycystic ovary syndrome (PCOS) has been redefined from a symptom-based condition to a biologically complex disorder with distinct genetic, developmental and phenotypic features. Translating these advances into precision diagnostics, early interventions and equitable care is essential to improve outcomes.

    • Bulent O. Yildiz
    Comments & Opinion
    Nature Reviews Endocrinology
    Volume: 21, P: 668-670

  • Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Here, Azziz et al. describe the current state of knowledge regarding the epidemiology, pathophysiology, diagnosis, management and future investigational directions of the disorder.

    • Ricardo Azziz
    • Enrico Carmina
    • Bulent O. Yildiz
    Reviews
    Nature Reviews Disease Primers
    Volume: 2, P: 1-18