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Showing 1–7 of 7 results
Advanced filters: Author: Burcak Otlu Clear advanced filters

  • An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as air pollution and passive smoking.

    • Marcos Díaz-Gay
    • Tongwu Zhang
    • Maria Teresa Landi
    Research
    Nature
    Volume: 644, P: 133-144

  • Analysis of genomic data from 981 colorectal cancers from participants in 11 countries reveals variations in mutational signatures of microsatellite-stable cancers that are dependent on geographical origin and age at which the cancer was diagnosed.

    • Marcos Díaz-Gay
    • Wellington dos Santos
    • Ludmil B. Alexandrov
    ResearchOpen Access
    Nature
    Volume: 643, P: 230-240

  • Whole-genome sequencing of 962 clear cell renal cell carcinomas from 11 countries shows geographic variations in somatic mutation profiles, including a mutational signature of unknown cause in 70% of cases from Japan.

    • Sergey Senkin
    • Sarah Moody
    • Paul Brennan
    ResearchOpen Access
    Nature
    Volume: 629, P: 910-918

  • Whole-genome sequencing of lung cancer in never smokers identifies different copy number subtypes and shows a lack of tobacco smoking signatures, even in cases exposed to secondhand smoke.

    • Tongwu Zhang
    • Philippe Joubert
    • Maria Teresa Landi
    Research
    Nature Genetics
    Volume: 53, P: 1348-1359

  • Many tumours are heterogenous, which calls into question whether multiple biopsies are required to accurately assess the cancer. Here, the authors show that papillary renal cell carcinoma is clonal in nature, suggesting that in this cancer one biopsy is sufficient for diagnosis and molecular analyses.

    • Bin Zhu
    • Maria Luana Poeta
    • Maria Teresa Landi
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Nail polish dryers commonly emit ultraviolet A (UVA) light, but the effects of this irradiation on mammalian cells remain unclear. Here, the authors examine the effects of UVA irradiation by a nail polish dryer on the genomes of mammalian cell lines, finding high levels of reactive oxygen species and related mutational signatures.

    • Maria Zhivagui
    • Areebah Hoda
    • Ludmil B. Alexandrov
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14