Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–2 of 2 results
Advanced filters: Author: Buyao Li Clear advanced filters

  • Lipid nanoparticles (LNPs) are a promising platform for mRNA delivery, but their use in inflammatory pulmonary diseases is limited by reactogenicity and suboptimal delivery. Here, the authors report a VATPase activating non-inflammatory LNP (NIF-LNP) exhibiting a 40fold enhancement in lung protein expression without causing significant reactogenicity compared to commercial LNPs.

    • Zhiqiang Zhao
    • Xinzhu Shan
    • Lei Miao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Metabolic dysfunction-associated steatohepatitis (MASH) poses challenges for targeted delivery and retention of therapeutic proteins due to excess extracellular matrix (ECM). To address this, the authors developed a “Fibrosis Overexpression and Retention (FORT) strategy” that can improve mRNA expression in the fibrotic region and extend the expressed protein in situ.

    • Xinzhu Shan
    • Zhiqiang Zhao
    • Lei Miao
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20