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Showing 1–3 of 3 results
Advanced filters: Author: Byunghee Koh Clear advanced filters

  • Fine-mapping has previously implicated the non-coding single nucleotide polymorphism rs117701653 as a risk variant for rheumatoid arthritis and type 1 diabetes, however its function remained unclear. Here the authors show that this variant decreases binding of the inhibitory factor SMCHD1 to enhance expression of ICOS, promoting development of potentially pathogenic T peripheral helper cells.

    • Taehyeung Kim
    • Marta Martínez-Bonet
    • Peter A. Nigrovic
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the immune response to disease.

    • Yongyao Fu
    • Jocelyn Wang
    • Mark H. Kaplan
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Interleukin-9 (IL-9) is important for allergy, autoimmunity and tumor immunity, but how its expression is regulated is unclear. Here the authors show the essential function of an enhancer, CNS-25 in mouse and CNS-18 in human, for IL-9 expression, with the deletion of this enhancer severely hampering IL-9 production in mice or human cells.

    • Byunghee Koh
    • Amina Abdul Qayum
    • Mark H. Kaplan
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16