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Showing 1–8 of 8 results
Advanced filters: Author: Cédric Delevoye Clear advanced filters

  • Caveolae are plasma membrane invaginations playing crucial functions, like signal transduction and mechanoprotection. Here, the authors show that caveolae contribute to skin pigmentation by integrating the biochemical and mechanical response of epidermal melanocytes to extracellular cues.

    • Lia Domingues
    • Ilse Hurbain
    • Cédric Delevoye
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The anterograde movement of Golgi-derived vesicles requires the small GTPase RAB6, while its effector ELKS targets these vesicles to particular areas of the plasma membrane. Here the authors show that RAB6 and ELKS function in the biogenesis of melanosome, demonstrating that the secretory pathway can be directed towards intracellular organelles of endosomal origin.

    • Anand Patwardhan
    • Sabine Bardin
    • Cédric Delevoye
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Canon et al. offer insights into the auto-inhibition and activation of the minus-end directed motor myosin VI. The work highlights how differential relief of auto-inhibition allows for fine control of myosin VI activity in vivo.

    • Louise Canon
    • Carlos Kikuti
    • Anne Houdusse
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • The activity of melanocytes determines skin pigmentation, and is regulated by a tight dialogue with keratinocytes. Here, the authors show that exosomes released by keratinocytes have a direct effect on melanocyte function, and exosome content is dependent on skin phototype and is modulated by ultraviolet B radiation.

    • Alessandra Lo Cicero
    • Cédric Delevoye
    • Graça Raposo
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Aktary et al. identify novel roles for the dynein light chain Dynlt3 in melanosome transport, maturation, and transfer to keratinocytes. They also find that the Wnt/βcatenin signalling pathway controls Dynlt3 levels and thus also contributes to the regulation of melanocyte transport and skin pigmentation.

    • Zackie Aktary
    • Alejandro Conde-Perez
    • Lionel Larue
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15