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Showing 1–50 of 76 results

Advanced filters: Author: C A Dinarello Clear advanced filters

Effect of an Interleukin-1 Receptor Antagonist on the Hemodynamic Manifestations of Group B Streptococcal Sepsis

Julio D Vallette JR.
Ronald N Goldberg
Eduardo Bancalari
Research01 Nov 1995
Pediatric Research

Volume: 38, P: 704-708
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee
Jeffrey T. Laydon
Peter R. Young
Research29 Dec 1994
Nature

Volume: 372, P: 739-746
Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

Stephen P. Eisenberg
Ron J. Evans
Robert C. Thompson
Research25 Jan 1990
Nature

Volume: 343, P: 341-346
Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

Charles H. Hannum
Carol J. Wilcox
Robert C. Thompson
Research25 Jan 1990
Nature

Volume: 343, P: 336-340
Severity of Elastase-Induced Emphysema Is Decreased in Tumor Necrosis Factor-α and Interleukin-1β Receptor-Deficient Mice

Edgar C Lucey
Joseph Keane
Ronald H Goldstein
Research01 Jan 2002
Laboratory Investigation

Volume: 82, P: 79-85
Autocrine angiogenic vascular prosthesis with bone marrow transplantation

Yasuharu Noishiki
Yasuko Tomizawa
Akihiko Matsumoto
Research01 Jan 1996
Nature Medicine

Volume: 2, P: 90-93
Tumor Necrosis Factor-α in Human Milk

H Elizabeth Rudloff
Frank C Schmalstieg Jr.
Armond S Goldman
Research01 Jan 1992
Pediatric Research

Volume: 31, P: 29-33
Newly discovered role for Fas ligand in the cell-cycle arrest of CD4⁺ T cells

Julie Desbarats
Richard C. Duke
M. Karen Newell
Research01 Dec 1998
Nature Medicine

Volume: 4, P: 1377-1382
Tumour necrosis factor in man: Clinical and biological observations

P Selby
S Hobbs
T Shiga
Research01 Dec 1987
British Journal of Cancer

Volume: 56, P: 803-808
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease

Multiple cytokines in the proinflammatory IL-1 family share the co-receptor IL-1R3. Dinarello and colleagues show that a fully humanized antibody to IL-1R3 can effectively control inflammation and disease mediated not only by IL-1 but also by IL-33 and IL-36.

Jesper Falkesgaard Højen
Marie Louise Vindvad Kristensen
Charles A. Dinarello
Research19 Aug 2019
Nature Immunology

Volume: 20, P: 1138-1149
Clone controversy at Immunex

SHELDON M. WOLFF
PHILIP E. AURON
ALEXANDER RICH
Research23 Jan 1986
Nature

Volume: 319, P: 270
A newly defined interleukin-1?

J. Fernando Bazan
Jackie C. Timans
Robert A. Kastelein
Research15 Feb 1996
Nature

Volume: 379, P: 591
Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

D. B. Carter
M. R. Deibel Jr
D. E. Tracey
Research12 Apr 1990
Nature

Volume: 344, P: 633-638
Effect of obesity and insulin on immunity in non-insulin-dependent diabetes mellitus

N Mito
T Hiyoshi
K Sato
Research27 Mar 2002
European Journal of Clinical Nutrition

Volume: 56, P: 347-351
A polymorphism of the interleukin-1 β gene influences survival in pancreatic cancer

M D Barber
J J Powell
J A Ross
ResearchOpen Access14 Nov 2000
British Journal of Cancer

Volume: 83, P: 1443-1447
Neurones express high levels of a structurally modified, activated form of pp60^c-src

Joan S. Brugge
Patricia C. Cotton
Robert W. Keane
Research01 Aug 1985
Nature

Volume: 316, P: 554-557
Tumour necrosis factor-alpha enhances the cytolytic and cytostatic capacity of interleukin-2 activated killer cells

A Matossian-Rogers
C Browne
H Festenstein
Research01 Apr 1989
British Journal of Cancer

Volume: 59, P: 573-577
Therapeutic potentiation of the immune system by costimulatory Schiff-base-forming drugs

J. Rhodes
H. Chen
B. Zheng
Research07 Sept 1995
Nature

Volume: 377, P: 71-75
Effect of Interleukin-1β on Plasma ACTH, β-Endorphin, and Corticosterone Levels in Infant and Prepubertal Rats

István Barna
Zsuzsanna Ács
James I Koenig
Research01 Jun 1995
Pediatric Research

Volume: 37, P: 714-719
Cancer phenotype as the outcome of an evolutionary game between normal and malignant cells

D Dingli
F A C C Chalub
J M Pacheco
ResearchOpen Access01 Sept 2009
British Journal of Cancer

Volume: 101, P: 1130-1136
Suppression of in vitro haematopoiesis following human immunodeficiency virus infection

Robert E. Donahue
Margaret M. Johnson
Jerome E. Groopman
Research01 Mar 1987
Nature

Volume: 326, P: 200-203
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

B. Beutler
D. Greenwald
A. Cerami
Research01 Aug 1985
Nature

Volume: 316, P: 552-554
Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

Kjell Ohlsson
Peter Björk
Robert C. Thompson
Research06 Dec 1990
Nature

Volume: 348, P: 550-552
Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum

A. R. Berendt
D. L. Simmons
K. Marsh
Research07 Sept 1989
Nature

Volume: 341, P: 57-59
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

Kevin J. Tracey
Yuman Fong
Anthony Cerami
Research23 Dec 1987
Nature

Volume: 330, P: 662-664
Caspase activation without death

A Zeuner
A Eramo
R De Maria
Reviews24 Nov 1999
Cell Death & Differentiation

Volume: 6, P: 1075-1080
Interleukin 1β mediates the modulatory effects of monocytes on LNCaP human prostate cancer cells

Z Culig
A Hobisch
G Konwalinka
Research01 Oct 1998
British Journal of Cancer

Volume: 78, P: 1004-1011
IL-6 promoter polymorphisms in rheumatoid arthritis

M Pascual
A Nieto
J Martín
Research15 Jun 2000
Genes & Immunity

Volume: 1, P: 338-340
Correction: Corrigendum: IL-37 protects against obesity-induced inflammation and insulin resistance

Dov B. Ballak
Janna A. van Diepen
Rinke Stienstra
Amendments and Corrections12 Jan 2015
Nature Communications

Volume: 6, P: 1
Obligatory wounding requirement for tumorigenesis in v-jun transgenic mice

Andre C. Schuh
Sarah J. Keating
Martin L. Breitman
Research23 Aug 1990
Nature

Volume: 346, P: 756-760
Interleukin-18 Induces Rheumatoid Arthritis Synovial Fibroblast CXC Chemokine Production through NFκB Activation

Jacques C M Morel
Christy C Park
Alisa E Koch
Research01 Oct 2001
Laboratory Investigation

Volume: 81, P: 1371-1383
IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

IL-1-mediated inflammation contributes to the pathogenesis of cystic fibrosis. Here the authors show that this is largely due to NLRP3 activation, whereas NLRP4 induces IL-1Ra, limiting the overall inflammasome activity and providing a therapeutic angle to ameliorate the disease.

Rossana G. Iannitti
Valerio Napolioni
Luigina Romani
ResearchOpen Access14 Mar 2016
Nature Communications

Volume: 7, P: 1-16
Compliance of bacterial flagella measured with optical tweezers

Steven M. Block
David F. Blair
Howard C. Berg
Research06 Apr 1989
Nature

Volume: 338, P: 514-518
International nomenclature guidelines for the IL-1 family of cytokines and receptors

Joseph M. Gaballa
Jesper Falkesgaard Højen
Diana Boraschi
Correspondence18 Mar 2024
Nature Immunology

Volume: 25, P: 581-582
The glittering prizes

The Nobel Prizes will be announced at the beginning of October. Is there a possibility that immunology might make the list?

Peter C Doherty
Comments & Opinion01 Oct 2010
Nature Immunology

Volume: 11, P: 875-878
IL-37 protects against obesity-induced inflammation and insulin resistance

Inflammation is a hallmark of obesity and driver of various associated pathologies. Here the authors show that mice overexpressing the anti-inflammatory cytokine IL-37 are protected from the metabolic consequences of a high-fat diet, and that plasma levels of IL-37 correlate with insulin sensitivity in humans.

Dov B. Ballak
Janna A. van Diepen
Rinke Stienstra
Research03 Sept 2014
Nature Communications

Volume: 5, P: 1-13
Activation of cyclin A-dependent kinases associated with WAF1 degradation during radiation-induced apoptosis

Tei Wei
Richard T Williams
Martin F Lavin
Research01 May 1997
Cell Death & Differentiation

Volume: 4, P: 276-282
Chemokinetic Agents for Monocytes in Human Milk: Possible Role of Tumor Necrosis Factor-α

Akram A Mushtaha
Frank C Schmalstieg
Armond S Goldman
Research01 Jun 1989
Pediatric Research

Volume: 25, P: 629-633
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

IL-37 is a member of the IL-1 family with profound anti-inflammatory functions. Nold and colleagues identify the receptor for IL-37 and clarify the molecular nature of the anti-inflammatory pathway induced by this cytokine.

Claudia A Nold-Petry
Camden Y Lo
Marcel F Nold
Research02 Mar 2015
Nature Immunology

Volume: 16, P: 354-365
Purification and Characterization of Human Interleukin–1 Expressed in Escherichia coli

Shirley R. Kronheim
Michael A. Cantrell
Thomas P. Hopp
Research01 Dec 1986
Bio/Technology

Volume: 4, P: 1078-1082
Interleukin-1α is the major alarmin of lung epithelial cells released during photodynamic therapy to induce inflammatory mediators in fibroblasts

E C Tracy
M J Bowman
H Baumann
ResearchOpen Access20 Sept 2012
British Journal of Cancer

Volume: 107, P: 1534-1546
IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals

J H Oh
M-C Cho
J T Hong
ResearchOpen Access21 Mar 2011
Oncogene

Volume: 30, P: 3345-3359
Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

Autophagocytic disposal of mitochondria (mitophagy) is important for regulating inflammation. Kanneganti and colleagues show that RIP2 kinase–initiated mitophagy is critical for dampening virally triggered immunopathology.

Christopher Lupfer
Paul G Thomas
Thirumala-Devi Kanneganti
Research24 Mar 2013
Nature Immunology

Volume: 14, P: 480-488
Toll-like receptors and chronic inflammation in rheumatic diseases: new developments

In the past few years, substantial progress has been made in our understanding of the role of Toll-like receptors (TLRs) in inflammatory diseases. Joosten and colleagues discuss the role of TLRs in the pathophysiology of rheumatic diseases and how TLRs and TLR signalling pathways can be targeted to treat these conditions.

Leo A. B. Joosten
Shahla Abdollahi-Roodsaz
Mihai G. Netea
Reviews12 May 2016
Nature Reviews Rheumatology

Volume: 12, P: 344-357
IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis

Michelle S. M. A. Damen
Rabia Agca
Calin D. Popa
ResearchOpen Access30 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
Interleukin 1α and the inflammatory process

IL-1α is a ubiquitously expressed cytokine that has diverse roles in immunity and homeostasis. Di Paolo and Shayakhmetov review IL-1α's distinctive and important role in inflammation.

Nelson C Di Paolo
Dmitry M Shayakhmetov
Reviews19 Jul 2016
Nature Immunology

Volume: 17, P: 906-913
IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting

In this Review, the authors summarize the pathophysiological mechanisms of IL-1-mediated autoinflammation. They describe the epidemiological and clinical features of autoinflammatory diseases, challenges associated with diagnostics and disease management, and current and future therapies for targeting the IL-1 pathway.

Lori Broderick
Hal M. Hoffman
Reviews21 Jun 2022
Nature Reviews Rheumatology

Volume: 18, P: 448-463
A phase I trial of recombinant human interleukin-1β(OCT-43) following high-dose chemotherapy and autologous bone marrow transplantation

M Elkordy
M Crump
WP Peters
Research01 Feb 1997
Bone Marrow Transplantation

Volume: 19, P: 315-322
Identification of novel single nucleotide polymorphisms in intron 1B and exon 1C of the human interleukin-1 receptor type I (IL-1RI) gene

D Sitara
O Olomolaiye
J Bidwell
Research03 Nov 1999
Genes & Immunity

Volume: 1, P: 161-163
Endothelial cell support of hematopoiesis is differentially altered by IL-1 and glucocorticoids

B Jazwiec
A Solanilla
J Ripoche
Research12 Aug 1998
Leukemia

Volume: 12, P: 1210-1220

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