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Showing 1–50 of 65 results

Advanced filters: Author: C Copland Clear advanced filters

Swamp cancer

P. K. C. AUSTWICK
J. W. COPLAND
Research01 Jul 1974
Nature

Volume: 250, P: 84
Scientific Centenaries in 1949

EDGAR C. SMITH
Research01 Jan 1949
Nature

Volume: 163, P: 11-13
Sequential BCR::ABL1 evaluation during dose de-escalation in peripheral blood is more predictive of TFR success than single assessment at dose de-escalation in either peripheral blood or bone marrow

S. D. Patterson
A. Gottschalk
I. Roeder
ResearchOpen Access07 Jan 2026
Leukemia

P: 1-5
BRD4-mediated repression of p53 is a target for combination therapy in AML

MDM2 and BET inhibitors have shown efficacy in AML treatment. Here, the authors show that the two compounds can synergize through both p53 protein stabilization and inhibition of BRD4-mediated repression of p53 target genes.

Anne-Louise Latif
Ashley Newcombe
Peter D. Adams
ResearchOpen Access11 Jan 2021
Nature Communications

Volume: 12, P: 1-16
Loss of type III transforming growth factor-β receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma

S J Cooper
H Zou
J A Copland
Research08 Mar 2010
Oncogene

Volume: 29, P: 2905-2915
Preferential elution of strong acids from a Norwegian ice cap

T. D. Davies
C. E. Vincent
P. Brimblecombe
Research11 Nov 1982
Nature

Volume: 300, P: 161-163
Beryllium in the water column of the central North Pacific

C.I. Measures
J. M. Edmond
Research06 May 1982
Nature

Volume: 297, P: 51-53
Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England

COVID-19 vaccines reduce the risk of severe disease in young people, but the absolute risk is low, and side effects have been reported. Here, the authors use data on 5–17 year olds in England to assess the overall risk-benefit profile of the vaccines.

Emma Copland
Martina Patone
Julia Hippisley-Cox
ResearchOpen Access27 May 2024
Nature Communications

Volume: 15, P: 1-14
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche

The function of macrophages in myeloid leukaemia can be difficult to assess because of lack of differentiation between transformed and non-transformed cells. Here the authors use a chimeric mouse model to characterise the effect of myeloid leukaemia on bystander macrophages noting altered functional properties of these cells.

Amy Dawson
Martha M. Zarou
G. Vignir Helgason
ResearchOpen Access05 Feb 2024
Nature Communications

Volume: 15, P: 1-19
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing

The role of folate metabolism in leukemic stem cells remains understudied. Here, the authors show that inhibition of mitochondrial folate metabolism leads to differentiation of leukemic cells through depletion of purines and suppression of mTORC1.

Martha M. Zarou
Kevin M. Rattigan
G. Vignir Helgason
ResearchOpen Access02 Mar 2024
Nature Communications

Volume: 15, P: 1-18
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

An analysis of blood samples from longitudinal cohorts reveals insights on the dynamics of clonal hematopoiesis of indeterminate potential and proposes a model that could be used for individualized clone monitoring over time.

Neil A. Robertson
Eric Latorre-Crespo
Tamir Chandra
ResearchOpen Access04 Jul 2022
Nature Medicine

Volume: 28, P: 1439-1446
Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease

The inability of tyrosine kinase inhibitors to eliminate quiescent leukaemic stem cells (LSC) in chromic myeloid leukaemia (CML) results in recurrence. Here, the authors identify a reliance of CML LSCs on low P53 expression for self-renewal and therapeutically target this by combining an MDM2 inhibitor with TKI in preclinical models of CML.

Mary T. Scott
Wei Liu
David Vetrie
ResearchOpen Access22 Jan 2024
Nature Communications

Volume: 15, P: 1-15
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells

The persistence of leukemic stem cells (LSCs) is known to limit the success of imatinib in patients with chronic myeloid leukaemia (CML). Here, the authors identify a reliance of these persisting LSCs on pyruvate carboxylase mediated pyruvate anaplerosis for survival after imatinib and demonstrate the therapeutic efficacy of targeting this using an inhibitor of mitochondrial pyruvate carrier.

Kevin M. Rattigan
Zuzana Brabcova
G. Vignir Helgason
ResearchOpen Access17 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Dr. Alexander Wood

G. F. C. SEARLE
Comments & Opinion17 Jun 1950
Nature

Volume: 165, P: 956
The unquantified mass loss of Northern Hemisphere marine-terminating glaciers from 2000–2020

As glaciers terminate into the ocean, mass is lost through frontal ablation where the ice meets the ocean. Here the authors estimate decadal frontal ablation from 2000 to 2020 of 1496 glaciers in the Northern Hemisphere, and find that frontal ablation makes up 79% of ice discharge to the ocean.

William Kochtitzky
Luke Copland
Francisco Navarro
ResearchOpen Access11 Oct 2022
Nature Communications

Volume: 13, P: 1-10
The Adelaide Meeting of the Australasian Association

E. C. ANDREWS
News13 Dec 1924
Nature

Volume: 114, P: 877
Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

Leukaemic stem cells (LSCs) are responsible for BCR–ABL-driven chronic myeloid leukaemia relapse; here, p53 and MYC signalling networks are shown to regulate LSCs concurrently, and targeting both these pathways has a synergistic effect in managing the disease.

Sheela A. Abraham
Lisa E. M. Hopcroft
Tessa L. Holyoake
Research08 Jun 2016
Nature

Volume: 534, P: 341-346
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia

In chronic myelogenous leukemia, leukemia stem cell function requires a microRNA that is provided by bone marrow endothelial cells.

Bin Zhang
Le Xuan Truong Nguyen
Guido Marcucci
Research05 Mar 2018
Nature Medicine

Volume: 24, P: 450-462
Nanotopography reveals metabolites that maintain the immunomodulatory phenotype of mesenchymal stromal cells

Mesenchymal Stromal Cells are hard to expand whilst retaining immunomodulatory properties due to spontaneous differentiation and ageing in culture. Here, the authors describe a mechanotransductive link between metabolism and functional activity and identify bioactive metabolites to expand functional MSCs at cell therapy scale.

Ewan A. Ross
Lesley-Anne Turner
Matthew J. Dalby
ResearchOpen Access10 Feb 2023
Nature Communications

Volume: 14, P: 1-16
Manifestations and mechanisms of the Karakoram glacier Anomaly

Glaciers in the Karakoram region, with their balanced or slightly positive mass balance, stand out from global glacier shrinkage, but this anomaly is not expected to persist in the long term, according to an overview of the possible explanations.

Daniel Farinotti
Walter W. Immerzeel
Amaury Dehecq
Reviews06 Jan 2020
Nature Geoscience

Volume: 13, P: 8-16
Genetic programming of macrophages generates an in vitro model for the human erythroid island niche

In vitro differentiation of red blood cells (RBCs) is a desirable therapy for various disorders. Here the authors develop a culture system using stem cell-derived macrophages to show that inducible expression of a transcription factor, KLF1, enhances RBC production, potentially through the induction of three soluble factors, ANGPTL7, IL33 and SERPINB2.

Martha Lopez-Yrigoyen
Cheng-Tao Yang
Lesley M. Forrester
ResearchOpen Access20 Feb 2019
Nature Communications

Volume: 10, P: 1-11
Author Correction: Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England

Emma Copland
Martina Patone
Julia Hippisley-Cox
Amendments and CorrectionsOpen Access08 Jul 2024
Nature Communications

Volume: 15, P: 1
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era – analysis of the European LeukemiaNet Blast Phase Registry

Annamaria Brioli
Elza Lomaia
Michael Lauseker
ResearchOpen Access28 Mar 2024
Leukemia

Volume: 38, P: 1072-1080
Recent Work of Geological Surveys

G. A. J. C.
News27 Jan 1910
Nature

Volume: 82, P: 380-382
Combined Population Dynamics and Entropy Modelling Supports Patient Stratification in Chronic Myeloid Leukemia

Marc Brehme
Steffen Koschmieder
Andreas Schuppert
ResearchOpen Access06 Apr 2016
Scientific Reports

Volume: 6, P: 1-12
Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells

C S Pichot
S M Hartig
S J Corey
ResearchOpen Access09 Jun 2009
British Journal of Cancer

Volume: 101, P: 38-47
Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer

Thomas C. Beadnell
Kelsey W. Nassar
Rebecca E. Schweppe
ResearchOpen Access28 Feb 2018
Oncogenesis

Volume: 7, P: 1-14
A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease

G. A. Horne
J. Stobo
M. Copland
Research10 Jan 2020
Leukemia

Volume: 34, P: 1775-1786
Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors

H Konig
M Holtz
R Bhatia
Research14 Feb 2008
Leukemia

Volume: 22, P: 748-755
BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia

Narissa Parry
Caroline Busch
Mhairi Copland
ResearchOpen Access15 Nov 2022
Cell Death Discovery

Volume: 8, P: 1-13
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML

This Review discusses many of the similarities and differences between leukaemia stem cells (LSCs) in chronic myeloid leukaemia and acute myeloid leukaemia and examines the therapeutic strategies that could be used to eradicate these LSCs.

David Vetrie
G. Vignir Helgason
Mhairi Copland
Reviews06 Jan 2020
Nature Reviews Cancer

Volume: 20, P: 158-173
Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML

Wittawat Chantkran
Ya-Ching Hsieh
Mhairi Copland
ResearchOpen Access10 Jun 2021
Cell Death Discovery

Volume: 7, P: 1-14
Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal

Parto Toofan
Caroline Busch
Helen Wheadon
ResearchOpen Access11 Sept 2018
Cell Death & Disease

Volume: 9, P: 1-19
CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy

Ross Kinstrie
Gillian A. Horne
Mhairi Copland
ResearchOpen Access02 Jan 2020
Leukemia

Volume: 34, P: 1613-1625
Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation

Vilma Dembitz
Hannah Lawson
Paolo Gallipoli
ResearchOpen Access26 Aug 2024
Leukemia

Volume: 38, P: 2395-2409
Multicolor quantitative confocal imaging cytometry

This resource paper describes the steps involved in carrying out quantitative multicolour imaging in tissue. It is applied to cleared mouse bone and plots the spatial distribution of specific cell populations within the marrow.

Daniel L Coutu
Konstantinos D Kokkaliaris
Timm Schroeder
Research13 Nov 2017
Nature Methods

Volume: 15, P: 39-46
Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia

David A. Irvine
Bin Zhang
Mhairi Copland
ResearchOpen Access09 May 2016
Scientific Reports

Volume: 6, P: 1-13
Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy

Andrew J. Innes
Chloe Hayden
Dragana Milojkovic
ResearchOpen Access17 Sept 2024
Leukemia

Volume: 38, P: 2443-2455
Cancer stem cell definitions and terminology: the devil is in the details

This article outlines some of the issues surrounding the terminology used for cancer stem cells (CSCs) and how CSCs are defined, with an aim to develop a consensus. More precise reporting of parameters used to identify CSCs is also recommended to enhance our understanding of CSC biology and to ultimately eradicate these cells in patients.

Peter Valent
Dominique Bonnet
Connie Eaves
Reviews11 Oct 2012
Nature Reviews Cancer

Volume: 12, P: 767-775
In a 12-allele analysis HLA-DPB1 matching is associated with improved OS in leukaemic and myelodysplastic patients receiving myeloablative T-cell-depleted PBSCT from unrelated donors

C Burt
A Parker
A Clark
Research17 Feb 2014
Bone Marrow Transplantation

Volume: 49, P: 657-663
A prospective study of real-time panfungal PCR for the early diagnosis of invasive fungal infection in haemato-oncology patients

N E Jordanides
E K Allan
B L Jones
Research10 Jan 2005
Bone Marrow Transplantation

Volume: 35, P: 389-395
Redifferentiation and induction of tumor suppressors miR-122 and miR-375 by the PAX8/PPARγ fusion protein inhibits anaplastic thyroid cancer: a novel therapeutic strategy

H V Reddi
C B Driscoll
N L Eberhardt
Research19 Apr 2013
Cancer Gene Therapy

Volume: 20, P: 267-275
The potential role for prolactin-inducible protein (PIP) as a marker of human breast cancer micrometastasis

J W Clark
L Snell
P H Watson
ResearchOpen Access29 Oct 1999
British Journal of Cancer

Volume: 81, P: 1002-1008
Spred1 deficit promotes treatment resistance and transformation of chronic phase CML

Junjing Qiao
Chen Liang
Guido Marcucci
Research25 Sept 2021
Leukemia

Volume: 36, P: 492-506
Correction to: Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML

Wittawat Chantkran
Ya-Ching Hsieh
Mhairi Copland
Amendments and CorrectionsOpen Access06 Jul 2021
Cell Death Discovery

Volume: 7, P: 1
Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-γ1-driven activation of mTOR/p70S6-kinase pathway

B Markova
C Albers
T Fischer
Research02 Nov 2009
Oncogene

Volume: 29, P: 739-751
ONYX-411, a conditionally replicative oncolytic adenovirus, induces cell death in anaplastic thyroid carcinoma cell lines and suppresses the growth of xenograft tumors in nude mice

H V Reddi
P Madde
N L Eberhardt
Research27 Jun 2008
Cancer Gene Therapy

Volume: 15, P: 750-757
Impact of combined ¹⁸F-FDG PET/CT in head and neck tumours

R Syed
J B Bomanji
P J Ell
ResearchOpen Access15 Mar 2005
British Journal of Cancer

Volume: 92, P: 1046-1050
Preclinical efficacy of the oncolytic measles virus expressing the sodium iodide symporter in iodine non-avid anaplastic thyroid cancer: a novel therapeutic agent allowing noninvasive imaging and radioiodine therapy

H V Reddi
P Madde
N L Eberhardt
Research13 Jul 2012
Cancer Gene Therapy

Volume: 19, P: 659-665
BCR-ABL activity and its response to drugs can be determined in CD34⁺ CML stem cells by CrkL phosphorylation status using flow cytometry

A Hamilton
L Elrick
T Holyoake
Research30 Mar 2006
Leukemia

Volume: 20, P: 1035-1039

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