Many tumours originate from cancer stem cells (CSCs), a small population of cells that display stem cell properties. Here Kanda and colleagues show that the lipid mediator, sphingosine-1 phosphate (S1P), enhances expansion of ALDH-positive CSCs via S1P receptor 3 (S1PR3) and subsequent Notch activation, providing a rationale for targeting S1PR3 in cancer.
- Naoya Hirata
- Shigeru Yamada
- Yasunari Kanda
