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Molecular Psychiatry (15)
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Showing 1–50 of 56 results

Advanced filters: Author: C M Middeldorp Clear advanced filters

Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma

The lack of appropriate models restricts pre-clinical research for nasopharyngeal carcinoma (NPC). Here the authors report the development and characterization of NPC patient-derived xenografts (PDXs), and EBV positive NPC cell line from patient tumor, and suggest their potential use in future NPC research.

Weitao Lin
Yim Ling Yip
Sai Wah Tsao
ResearchOpen Access07 Nov 2018
Nature Communications

Volume: 9, P: 1-17
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

Genome-wide association meta-analyses of attention-deficit/hyperactivity disorder symptom measures and clinical diagnoses identify new risk loci, highlight putative effector genes and yield improved polygenic risk scores.

Camiel M. van der Laan
Hill F. Ip
Dorret I. Boomsma
Research17 Sept 2025
Nature Genetics

Volume: 57, P: 2427-2435
Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X

It is known that hereditary factors contribute to familial colorectal cancer type X. Here, the authors uncover the SEMA4A p.Val78Met germline mutation and show that the protein product is associated with changes in cell cycle progression in colorectal cancer cells.

Eduard Schulz
Petra Klampfl
Heinz Sill
ResearchOpen Access13 Oct 2014
Nature Communications

Volume: 5, P: 1-11
Genetic and environmental influences interact with age and sex in shaping the human methylome

Differential impact of genetic and environmental influences on DNA methylation may result in sex- and age-related physiological variation and disease susceptibility. By analysing DNA methylome of 2,603 individuals from twin families, here, the authors establish a catalogue of between-individual variation in DNA methylation.

Jenny van Dongen
Michel G. Nivard
Dorret I. Boomsma
ResearchOpen Access07 Apr 2016
Nature Communications

Volume: 7, P: 1-13
Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

Camiel M. van der Laan
Hill F. Ip
Dorret I. Boomsma
Amendments and Corrections29 Sept 2025
Nature Genetics

Volume: 57, P: 2604
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and genetic overlap with ADHD and brain phenotypes.

Anna Gui
Anja Hollowell
Angelica Ronald
ResearchOpen Access07 May 2025
Nature Human Behaviour

Volume: 9, P: 1470-1487
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent risk loci. Comparisons with other psychiatric disorders and candidate gene analyses provide new insights into major depressive disorder.

Naomi R. Wray
Stephan Ripke
Patrick F. Sullivan
Research26 Apr 2018
Nature Genetics

Volume: 50, P: 668-681
Association studies on 11 published colorectal cancer risk loci

S von Holst
S Picelli
A Lindblom
ResearchOpen Access20 Jul 2010
British Journal of Cancer

Volume: 103, P: 575-580
The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

C M Middeldorp
M H M de Moor
D I Boomsma
ResearchOpen Access18 Oct 2011
Translational Psychiatry

Volume: 1, P: e50
Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression

Genome-wide association analyses leveraging Nordic biobanks with longitudinal health registries identify differences in the genetic architectures of early-onset and late-onset major depressive disorder and in their genetic correlations with related traits.

John R. Shorter
Joëlle A. Pasman
Yi Lu
ResearchOpen Access13 Nov 2025
Nature Genetics

Volume: 57, P: 2972-2979
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

A genome-wide association study for attention deficit/hyperactivity disorder (ADHD) identifies 12 loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.

Ditte Demontis
Raymond K. Walters
Benjamin M. Neale
Research26 Nov 2018
Nature Genetics

Volume: 51, P: 63-75
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

An integrated analysis of several cohorts shows that clonal, antigen-experienced T cells are found in the cerebrospinal fluid of patients with Alzheimer’s disease, suggesting that the adaptive immune system has a role in age-related neurodegeneration.

David Gate
Naresha Saligrama
Tony Wyss-Coray
Research08 Jan 2020
Nature

Volume: 577, P: 399-404
Author Correction: Epidemiology and modifiable risk factors for atrial fibrillation

Adrian D. Elliott
Melissa E. Middeldorp
Prashanthan Sanders
Amendments and Corrections17 Jan 2023
Nature Reviews Cardiology

Volume: 20, P: 429
Symptom-level modelling unravels the shared genetic architecture of anxiety and depression

Thorp et al. use symptom-level genetic modelling to identify 61 and 73 genomic loci associated with depression and anxiety, respectively, and reveal that they possess highly similar genetic architectures.

Jackson G. Thorp
Adrian I. Campos
Eske M. Derks
Research15 Apr 2021
Nature Human Behaviour

Volume: 5, P: 1432-1442
Early postnatal cardiac follow-up of survivors of twin–twin transfusion syndrome treated with fetoscopic laser coagulation

Manon Gijtenbeek
Monique C. Haak
Arend D. J. ten Harkel
Research09 Mar 2020
Journal of Perinatology

Volume: 40, P: 1375-1382
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects individually and their additive or interaction effects.

Darina Czamara
Gökçen Eraslan
Elisabeth B. Binder
ResearchOpen Access11 Jun 2019
Nature Communications

Volume: 10, P: 1-18
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

Colm O'Dushlaine
Lizzy Rossin
Gerome Breen
Research19 Jan 2015
Nature Neuroscience

Volume: 18, P: 199-209
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

Xueyi Shen
David M. Howard
Andrew M. McIntosh
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-16
Identification of common genetic risk variants for autism spectrum disorder

A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

Jakob Grove
Stephan Ripke
Anders D. Børglum
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 431-444
A two-phase case–control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22

A Abulí
C Fernández-Rozadilla
S Castellví-Bel
ResearchOpen Access02 Aug 2011
British Journal of Cancer

Volume: 105, P: 870-875
Assessing HCH isomer uptake in Alnus glutinosa: implications for phytoremediation and microbial response

Aday Amirbekov
Stanislava Vrchovecka
Alena Sevcu
ResearchOpen Access20 Feb 2024
Scientific Reports

Volume: 14, P: 1-14
Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference

H Rob Taal
Beate St Pourcain
James F Wilson
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 713
Common variants at 12q15 and 12q24 are associated with infant head circumference

Vincent Jaddoe and colleagues report a genome-wide association study for infant head circumference. They identify variants in SBNO1 and near HMGA2 that are associated with this phenotype.

H Rob Taal
Beate St Pourcain
James F Wilson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 532-538
A mega-analysis of genome-wide association studies for major depressive disorder

Stephan Ripke
Naomi R Wray
Patrick F Sullivan
Research03 Apr 2012
Molecular Psychiatry

Volume: 18, P: 497-511
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Lavinia Paternoster and colleagues report the results of a large, multi-ancestry genome-wide association study of atopic dermatitis. They identify ten new susceptibility loci harboring candidate genes involved in innate host defense and T cell function.

Lavinia Paternoster
Marie Standl
Stephan Weidinger
Research19 Oct 2015
Nature Genetics

Volume: 47, P: 1449-1456
Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?

Eshim S. Jami
Anke R. Hammerschlag
Christel Middeldorp
ResearchOpen Access18 Mar 2023
Translational Psychiatry

Volume: 13, P: 1-6
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

S Hong Lee
Stephan Ripke
Naomi R Wray
Research11 Aug 2013
Nature Genetics

Volume: 45, P: 984-994
Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume

M Arfan Ikram
Myriam Fornage
James F Wilson
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 713
Optimizing antithrombotic therapy in patients with coexisting cardiovascular and gastrointestinal disease

In this Review, the authors address considerations for enteral antithrombotic therapy in patients with cardiovascular disease and gastrointestinal comorbidities, who often have an increased risk of gastrointestinal bleeding. Approaches include tailoring of antithrombotic regimens and gastrointestinal-protection strategies.

Azita H. Talasaz
Parham Sadeghipour
Behnood Bikdeli
Reviews20 Mar 2024
Nature Reviews Cardiology

Volume: 21, P: 574-592
Effective T cell regeneration following high-dose chemotherapy rescued with CD34⁺ cell enriched peripheral blood progenitor cells in children

A Heitger
H Kern
D Niederwieser
Research12 Feb 1999
Bone Marrow Transplantation

Volume: 23, P: 347-353
Epidemiology and modifiable risk factors for atrial fibrillation

The global prevalence of atrial fibrillation (AF) is increasing, largely as a result of a rise in modifiable risk factors. In this Review, Sanders and colleagues summarize the epidemiology of AF and discuss lifestyle changes and risk factor interventions for the primary and secondary prevention of AF.

Adrian D. Elliott
Melissa E. Middeldorp
Prashanthan Sanders
Reviews04 Jan 2023
Nature Reviews Cardiology

Volume: 20, P: 404-417
A Rapid and Reliable Enzyme Immunoassay PCR-Based Screening Method to Identify EBV-Carrying Gastric Carcinomas

Josine van Beek
Axel zur Hausen
Adriaan J C van den Brule
Research01 Aug 2002
Modern Pathology

Volume: 15, P: 870-877
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Genetic association study of childhood aggression across raters, instruments, and age

Hill F. Ip
Camiel M. van der Laan
Dorret I. Boomsma
ResearchOpen Access30 Jul 2021
Translational Psychiatry

Volume: 11, P: 1-9
Common variants at 6q22 and 17q21 are associated with intracranial volume

M. Arfan Ikram and colleagues report a genome-wide association study for intracranial volume and brain volume. They report two loci associated with intracranial volume.

M Arfan Ikram
Myriam Fornage
James F Wilson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 539-544
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Research23 Jan 2020
Molecular Psychiatry

Volume: 25, P: 1430-1446
Genetic risk profiles for depression and anxiety in adult and elderly cohorts

A Demirkan
B W J H Penninx
C M Middeldorp
ResearchOpen Access22 Jun 2010
Molecular Psychiatry

Volume: 16, P: 773-783
Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder

Héléna A. Gaspar
Zachary Gerring
Gerome Breen
ResearchOpen Access15 Mar 2019
Translational Psychiatry

Volume: 9, P: 1-9
Erratum: Meta-analysis of genome-wide association studies of anxiety disorders

T Otowa
K Hek
J M Hettema
Amendments and Corrections09 Feb 2016
Molecular Psychiatry

Volume: 21, P: 1485
Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype

C M Middeldorp
J-J Hottenga
D I Boomsma
Research14 Aug 2007
Molecular Psychiatry

Volume: 13, P: 84-89
Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

R C Culverhouse
N L Saccone
L J Bierut
Research04 Apr 2017
Molecular Psychiatry

Volume: 23, P: 133-142
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Assessing differential application of thromboprophylaxis regimes related to risk of pulmonary embolism and mortality in COVID-19 patients through instrumental variable analysis

Linda Nab
Chantal Visser
P. M. van der Zee
ResearchOpen Access25 Mar 2025
Scientific Reports

Volume: 15, P: 1-15
Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes

Bradley T Webb
An-Yuan Guo
John M Hettema
Research04 Apr 2012
European Journal of Human Genetics

Volume: 20, P: 1078-1084
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Liz Rietschel
Fabian Streit
Marcella Rietschel
ResearchOpen Access10 Nov 2017
Scientific Reports

Volume: 7, P: 1-15
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

A Hinney
M Kesselmeier
J Hebebrand
Research17 May 2016
Molecular Psychiatry

Volume: 22, P: 192-201
A Bayesian Belief Network model to link sanitary inspection data to drinking water quality in a medium resource setting in rural Indonesia

D. Daniel
Widya Prihesti Iswarani
Luuk Rietveld
ResearchOpen Access02 Nov 2020
Scientific Reports

Volume: 10, P: 1-13
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

Simone de Jong
Mateus Jose Abdalla Diniz
Gerome Breen
ResearchOpen Access08 Oct 2018
Communications Biology

Volume: 1, P: 1-10
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned

N R Wray
M L Pergadia
P F Sullivan
ResearchOpen Access02 Nov 2010
Molecular Psychiatry

Volume: 17, P: 36-48
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

S H Witt
F Streit
M Rietschel
ResearchOpen Access20 Jun 2017
Translational Psychiatry

Volume: 7, P: e1155

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