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Showing 1–6 of 6 results
Advanced filters: Author: C Massignan Clear advanced filters

  • Spagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cellular prion protein, identifying ligands stabilizing a folding intermediate and consequently promoting its degradation by the cellular quality control machinery.

    • Giovanni Spagnolli
    • Tania Massignan
    • Emiliano Biasini
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-16

  • In 1970, Vitaly Efimov predicted that three interacting particles can form an infinite series of bound trimer states, even when none of the two-particle subsystems is stable. Experimental evidence for such an exotic state was obtained in 2006, but now an Efimov spectrum, containing two such states with the predicted scaling between them, has been observed.

    • M. Zaccanti
    • B. Deissler
    • G. Modugno
    Research
    Nature Physics
    Volume: 5, P: 586-591

  • The observation of a trimer resonance in an ultracold mixture of caesium atoms and dimers confirms one of the key predictions of three-body physics in the limit of resonant two-body interactions, with possible implications for understanding few-body states in nuclear matter.

    • S. Knoop
    • F. Ferlaino
    • R. Grimm
    Research
    Nature Physics
    Volume: 5, P: 227-230