Detailed characterization of the regulatory domain of a plasma-membrane Ca2+-ATPase — a calcium pump — in complex with calmodulin results in a two-step structural model that explains how calmodulin-mediated regulation of pump activation affords highly responsive control over the intracellular calcium concentration in eukaryotes.
- Henning Tidow
- Lisbeth R. Poulsen
- Poul Nissen