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Showing 1–3 of 3 results
Advanced filters: Author: C. Eliscovich Clear advanced filters

  • Chaperone mediated autophagy (CMA) is selective but its activity in different tissue types has been unclear due to a lack of tools. Here, the authors generate transgenic mice expressing a CMA reporter that provides spatial and temporal in vivo data, uncovering differences in CMA in distinct tissues.

    • S. Dong
    • C. Aguirre-Hernandez
    • A. M. Cuervo
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • This report uncovers a role for the mRNA binding factor CPEB4 in cancer. CEPB4 is upregulated in human pancreatic adenocarcinomas and glioblastomas, where it supports tumor growth by providing translational activation of normally silent mRNAs, including tPA, an important contributor to malignancy. The findings illustrate that altered post-transcriptional regulation of gene expression may be an important contributing factor to cancer.

    • Elena Ortiz-Zapater
    • David Pineda
    • Pilar Navarro
    Research
    Nature Medicine
    Volume: 18, P: 83-90