Although major histocompatibility complex (MHC) class II alleles and CD4+ T cells have been implicated in multiple sclerosis, Friese et al. provide here the first direct evidence incriminating MHC class I genes and CD8+ T cells in the pathogenesis of this autoimmune disorder (pages 1150–1151).
- Manuel A Friese
- Karen B Jakobsen
- Lars Fugger
