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Showing 1–7 of 7 results
Advanced filters: Author: C. Orelle Clear advanced filters

  • Lacabanne and Orelle et al. investigate a multidrug ABC transporter BmrA mutant defective in the X-loop, which uncouples ATP hydrolysis from substrate translocation. This study suggests that stiffening of a defined set of amino-acid residues allows the pump to transport substrates properly.

    • Denis Lacabanne
    • Cédric Orelle
    • Anja Böckmann
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-9

  • Authors present the structure of Ycf1p, a homolog of multidrug resistance protein 1 (MRP1). The monomeric and dimeric Ycf1p species are differentially phosphorylated and possess different ATPase activities indicating that dimerization affects the function of the protein.

    • Sarah C. Bickers
    • Samir Benlekbir
    • Voula Kanelis
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • A ribosome with tethered subunits, ‘Ribo-T’, is engineered by making a hybrid RNA composed of ribosomal RNA of large and small subunits; Ribo-T can support cell growth in vivo in the absence of wild-type ribosomes, and is used to establish a fully orthogonal ribosome–mRNA system.

    • Cédric Orelle
    • Erik D. Carlson
    • Alexander S. Mankin
    Research
    Nature
    Volume: 524, P: 119-124

  • The tethered ribosome system Ribo-T supports cell proliferation though at a reduced rate. Here the authors show this is due to slower ribosome assembly instead of reduced functionality.

    • Nikolay A. Aleksashin
    • Margus Leppik
    • Alexander S. Mankin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13