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Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS

MATR3 is an ALS-linked gene. Here the authors describe a mutant MATR3 knockin mouse, which mimics some aspects of early-stage ALS.

Ching Serena Kao
Rebekah van Bruggen
Jeehye Park
ResearchOpen Access20 Oct 2020
Nature Communications

Volume: 11, P: 1-17
Decreased left heart flow in fetal lambs causes left heart hypoplasia and pro-fibrotic tissue remodeling

A fetal lamb model of mitral stenosis shows that sustained reduction in fetal left heart flow causes left heart hypoplasia and sequencing analysis identifies changes associated with pro-fibrotic environment and aberrant induction of mesenchymal programs.

Miriam S. Reuter
Dustin J. Sokolowski
Rajiv R. Chaturvedi
ResearchOpen Access22 Jul 2023
Communications Biology

Volume: 6, P: 1-14

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Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS

Decreased left heart flow in fetal lambs causes left heart hypoplasia and pro-fibrotic tissue remodeling

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