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Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control

The role of synaptogenesis during the acquisition of goal-directed behaviors is unknown. Here, the authors show that learning-induced synaptogenesis in the adult mouse cortex is required to excite a specific circuit to adjust effort exertion.

Francesco Paolo Ulloa Severino
Oluwadamilola O. Lawal
Cagla Eroglu
ResearchOpen Access08 Sept 2023
Nature Communications

Volume: 14, P: 1-22
Chemico-genetic discovery of astrocytic control of inhibition in vivo

A cell-surface fragment complementation strategy is used to identify the proteome at the junction of astrocytes and synapses in vivo, and shows that NRCAM expressed in astrocytes has a key role in regulating inhibitory synapse function.

Tetsuya Takano
John T. Wallace
Scott H. Soderling
Research11 Nov 2020
Nature

Volume: 588, P: 296-302
Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis

Astrocyte morphogenesis depends on interactions between astrocytic neuroligins and neuronal neurexins.

Jeff A. Stogsdill
Juan Ramirez
Cagla Eroglu
Research09 Nov 2017
Nature

Volume: 551, P: 192-197
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

Delivering genes to and across the brain vasculature efficiently and specifically across species remains challenging. Here, the authors show that endothelial-specific AAVs with serotype flexibility enable redosing and transform the brain vasculature into an in vivo biofactory in genetically diverse rodents. In primates, these vectors cross the blood-brain-barrier and show broad tropism.

Xinhong Chen
Damien A. Wolfe
Viviana Gradinaru
ResearchOpen Access08 Jun 2023
Nature Communications

Volume: 14, P: 1-19
Mitochondrial transfer from glia to neurons protects against peripheral neuropathy

Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuropathy.

Jing Xu
Yize Li
Ru-Rong Ji
ResearchOpen Access07 Jan 2026
Nature

Volume: 650, P: 951-960
Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease

Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevated CK2α’ kinase and Fbxw7 E3 ligase expression.

Rocio Gomez-Pastor
Eileen T. Burchfiel
Dennis J. Thiele
ResearchOpen Access13 Feb 2017
Nature Communications

Volume: 8, P: 1-17
Astrocytic traffic jams in the aging brain

Lee and colleagues reveal a previously unrecognized population of astrocytes in the aged brain with disrupted proteostatic signaling that generates defects in astrocyte morphology, protein trafficking and synapse maintenance in the aging hippocampus.

Ryan Baumert
Nicholas Brose
Cagla Eroglu
News & Views01 Aug 2022
Nature Aging

Volume: 2, P: 681-683
Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4

This paper identifies a specific population of subventricular-zone-generated astrocytes that increases in population density after cortical injury; these activated astrocytes migrate to the site of injury, unlike described properties for their counterparts residing in the cortex.

Eric J. Benner
Dominic Luciano
Chay T. Kuo
Research24 Apr 2013
Nature

Volume: 497, P: 369-373
Neighbour-induced changes in root exudation patterns of buckwheat results in altered root architecture of redroot pigweed

Çağla Görkem Eroğlu
Alexandra A. Bennett
Aurélie Gfeller
ResearchOpen Access15 Apr 2024
Scientific Reports

Volume: 14, P: 1-17
Regulation of synaptic connectivity by glia

Cagla Eroglu
Ben A. Barres
Reviews10 Nov 2010
Nature

Volume: 468, P: 223-231
Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability

Takumi Taketomi
Takunori Yasuda
Fuminori Tsuruta
ResearchOpen Access13 Jul 2022
Scientific Reports

Volume: 12, P: 1-13

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